PHOTOCHEMICAL TRANSFORMATION OF FLOUROQUINOLONE ANTIBIOTIC DRUG- BESIFLOXACINAbstract
In the present study, the photochemistry of fluoroquinolone antibiotic drug-besifloxacin (1) was investigated under mild conditions similar to those encountered in biological systems namely aerobic as well as an anaerobic condition with UV-A light. When besifloxacin (1) was irradiated with a high-pressure mercury lamp under aerobic conditions it afforded 7-(2-Amino-5-oxo-pentylamino)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo- 1, 4 – dihydro-quinoline-3-carboxylic acid as photoproduct (2) and under anaerobic condition it afforded 7-(3-Amino-azepan-1-yl)-1-cyclo propyl-6-fluoro-8-hydroxy-4-oxo-1,4dihydro-quinoline-3-carboxylic acid as photoproduct (3). The formation of photoproduct was explained by the type-I and type II mechanism of photosensitization.
W. Ahmad*, A. Singh and P. Chaudhary
Department of Chemistry, Uttaranchal University, Dehradun - 248001, (U. K.), India.
09 May, 2015
02 September, 2015
18 September, 2015
30 September, 2015