NATURAL AND HERBAL STRESS REMEDIES: A REVIEWHTML Full Text
NATURAL AND HERBAL STRESS REMEDIES: A REVIEW
Aleza Rizvi*1, Anuradha Mishra1, Abbas Ali Mahdi 2, Mohd Ahmad 2 and Abdul Basit 2
Faculty of Pharmacy 1, Integral University, Lucknow, Uttar Pradesh, India
Department of Biochemistry 2, King George Medical University, Lucknow, Uttar Pradesh, India
ABSTRACT: The normal steady state of the human body’s organ and tissue function is termed as homeostasis. One significant factor that may cause an upset to homeostasis is stress. It is a fundamental part of living that can have both positive and negative effects on an individual’s health. Stress is not a medical diagnosis, but severe stress that continues for a long time may lead to a diagnosis of depression or anxiety, or more severe mental health problems. According to the W.H.O survey out of every three persons in the world one person affecting with the stress. There are various interventions for mind-body healing. Certain psychological mind-body therapies are effective for reducing stress. Nurses can use these interventions in their daily practice to help patients alleviate their stress, as well as enable them to recover successfully from stress-related problems. Prescription anxiety medications dull anxiety and the brain too much, and make it much harder to learn to cope with stress, while herbal and natural remedies keep your mind intact for learning to control stress and anxiety symptoms. Nature has bestowed our country with an enormous wealth of antistress plants .Some medicinal antistress plants are Coccinia indica, Butea frondosa, Cuminum cyminum etc. The aim of this review of this review is a comprehensive selection of the herbs that may be effective for treating stress, as well as specific anxiety symptoms. It includes the herbs that are effective for stress itself, as well as several herbal remedies that are perfect for issues related to stress.
|Keywords:Anti-stress, medicinal plants,|
mind- body therapies, W.H.O
INTRODUCTION: Stress is a common phenomenon that is experienced by every individual. 1 When stress become extreme it is harmful for the body, and hence to be treated. Stress is involved in the pathogenesis of a variety of diseases that includes psychiatric disorders such as depression and anxiety, immunosuppression, endocrine disorders including diabetes peptic ulcer, hypertension, cognitive dysfunction and ulcerative colitis.2
Stress has close connections with various dysfunctions of the body. It is a response of the body to the diverse aversive assaults, which threaten internal homeostasis. It is known to alter the physiological homeostasis of the organism and results in breakdown of integrated adaptational processes in response to extreme environmental stimulus. 3
Body reacts to such a situation by eliciting various autonomic, endocrinal and visceral responses in variety of situations, for e.g. release of hormones like cortisol and adrenalin.4 Disruptions of gastric mucosal integrity have been reported during stress. Both peripheral and central mechanisms seem to regulate these changes. These lead to an increased heart rate, B.P. and metabolic rate, all intended to increase the overall performance and ability of body to overcome challenge. But beyond threshold these factors can be damaging.5 Stress has been postulated to be involved in pathogenesis of variety of diseased states, for eg, psychiatric disorders like depression and anxiety, immunosuppression, endocrine disorders including diabetes mellitus, male impotency, cognitive dysfunction, peptic ulcer, hypertension and ulcerative colitis.6
In other words Stress is the body’s reaction to any stimuli that disturb its equilibrium. When the equilibrium of various hormones is altered the effect of these changes can be detrimental to the immune system. A stressful event can trigger the "fight-or-flight" response, causing hormones such as adrenaline and cortisol to surge through the body. A little bit of stress, known as "acute stress," can be exciting—it keeps us active and alert. But long-term, or "chronic stress," can have detrimental effects on health. You may not be able to control the stressors in your world, but you can alter your reaction to them.7, 8
Herbal formulations have been in use for many years not only in Asian countries but also globally humans well being. They claimed to enhance physical endurance, mental functions. The potential utility of safer and cheaper herbal medicines as anti-stress agents have been reported as they can withstand stress without altering the physiological functions of the body.9
Appraisal of stressors:
It must be pointed out that stress alone does not necessarily determine how well or poorly the immune system will function. The important factor is the individual’s ability to cope with stress. How an individual perceives a stressful event may be more important than the existence of the stress itself. Individuals with high stress levels and excellent coping skills may have minimal effects on the functioning of their immune systems. A low level of stress in individuals who have poor coping skills may have significant alterations in their immune functioning, increasing their susceptibility to disease. The actual amount of stress is not important for determining its effect on the immune system. An individual’s coping skills are the important factor for determining the immune system’s response to stress.10 Fig.1.
FIG.1: APPRAISAL OF STRESSORS
The effect of stress on the immune system:
The stress hormones released by the adrenals during episodes of fear and anxiety also affect white blood cells, the infection-fighting army within our blood. Initially, the surge of brain and adrenal hormones that accompanies stress causes an increase in circulating white blood cells. When cortisol remains high, however, white blood cell numbers are reduced. As stress, anxiety, or depression continue unabated over weeks or months, output of the adrenal hormone cortisol is consistently high and white blood cell numbers remain reduced.11
TABLE 1: SOME IMPORTANT HERBAL DRUGS TO REDUCE STRESS
|S.no||Plants name||Commonname||Chemical constituents||Pharmacological uses|
|Moringa oleifera||Drumstick||Palmitic , stearic acid, saponins,glycoside, gum, protein Vitamins: A, B1, B2, B3, C Minerals: calcium, iron, phosphorus, magnesium, pterygospermin, moringine
|Antimicrobial, anti-inflammatory, anticancer, antifertility,hepatoprotective, antioxidant, cardiovascular, antiepileptic, antiasthamatic, antidiabetic, diuretic, CNS, analgesic, antiulcer12|
|Butea frondosa||Palash||Tannic and gallic acids. Palasonin,sitosterol, amyrin, monospermin,
lectins and lactone.
The alkaloid palasonin.
Seeds: Glycerides of palmitic, Lignoceric,
oleic and linoleic acids.
Flower: monospermin, butrin and isobutrin13
|Antidiabetic, hepatoprotective,anti-inflammatory, anticonvulsant, antidiarrhoeal, antihelmintic, antioxidant 14 aphrodisiac,15 antifilarial,16 antistress,17 antiobessity 18|
|Ocimun bacilicum||Tulsi , Basil||Leaves: eugenol, eugenal, carvacrol, methylchavicol, limatrol and caryophylline. steroid ursolic acid and n-triacontanol.Seeds: Fatty acids and sitosterol.
Roots : sitosterol and three triterpenes A, B,
|Antioxidant, antimicrobial, cytotoxic, nematidical, Immunomodulatory,anti-inflammatory, Muscle Relexant , analgesic, CNS, antiprotozoal activity20|
|Centella asiatica||Indian pennywort||pentacyclic triterpenoids : asiaticoside, brahmoside, asiatic acid, and brahmic, centellose, centelloside, and madecassoside 21||Adaptogen, antibacterial, antiviral,anti-inflammatory, antiulcerogenic, anxiolytic, diuretic activity.22|
|Celestrus paniculatus||Black oil plant||Seeds:fatty acids and alkaloids 23||Emmenagogue , emetic, aphrodisiac, expectorant.24|
|6||Anemarrhena asphodeloides||Zhi Mu||Rhizome: Sarsasapogenin, saponins,xanthone glycosides, isoflavonoids,
and anthraquinone 25
|Anticancer, antidiabetic,antistress, anti-inflammatory, antiplatlet, antimicrobial, expectorant, diuretic, antiseptic, antianxiety, antifungal.25|
|7||Oenothera biennis||Evening primrose||Terpenoids, steroids, flavonoids,carbohydrates, lipids, linoleic acid,
oleic acid, stearic acid, palmitic acid
and saturated fatty acids26
|Antioxidant, cytotoxic,antibacterial, antiviral,anti-inflammatory, antihyperlipidiamic, thromblytic, anti-diarrhoeal.27|
|8||Verbascum thapsus||Mullein||Flavonoids, phenylethanoid glycosides,tri terpenes, saponins, polysaccharides,
phenolic acids, phytosterols28
|Antibacterial, antitumor, cardiovascular, anti-inflammatory, hepatoprotective, analgesic.28|
|Jeera||Fattyacids, triacyglycerols, polysaccarides, lignin, cuminaldehyde, limonene, pinene, linalool, flavonoids, isoflavonoids29||Antidiabetic, antistress30anti-epileptic, anti-nociceptive31 hepatoprotective,32 antibacterial,
|10||Maidenhair||leaves : flavonoid, glycosides (containing quercetin, kaempferol, isorhamnetinterpenoids (ginkgolides A, B, C, and J, bilobalide) organic acids 34||Antioxidant,anti-inflammatory,34 cardioprotective, anticancer,antistress activity35|
|11||Mikania cordata||Mile-a-minute||coumarins sesquiterpenes,sesquiterpenes lactones, diterpenes,
phytosterols/ terpenoids and flavonoids.36
|Antinociceptive, cytotoxic,antimicrobial, antibacterial, anti-inflammatory, analgesic,36 antivirucidal and antiparasitic activity37|
|12||Phyllanthus emblica||Amla||Fruit: hydrolysable tannins(emblicanin A and B), alkaloids,
phenolic compounds, minerals, protein
and amino acids: (glutamic acid, proline,
aspartic acid, alanine, cystine and lysine). Vitamin C, Flavonoids: quercetin, kaempferol 38
|antipyretic, analgesic, antitussive, adaptogenic, cardioprotective, gastroprotective, antianemic, antiinflamatory, antihypercholesterolemic,antidiarrheal, antipyretic, antiatherosclerotic, hepatoprotective, nephroprotective, and neuroprotective properties38|
|13||Alchornea cordifolia||Senegal||Leaves: alkaloids, saponins,unsaturated and carbonyl compounds, terpenoids, Root: steroid glycosides, flavonoids, tannins, saponins, carbohydrates phenolic acids, gallic acid, protocatechuic acid, quercetin, quercetin arabinose and galactose glycosides39||Antipyretic, anti-inflammatory, analgesic, antifungal, antibacterial, antidiarrhoeal, abortifacient, antispasmodic, blood purifier,diuretic, emetic40|
|14||Coccinia indica||Kundru||Aerial part : Heptacosane, Cephalandrol, β -sitosterol, Alkaloids Cephalandrins A and B,Fruits: β- Amyrin Acetate, Lupeol, Cucurbitacin B, Taraxerone, Taraxerol, β-carotene, Lycopene, Cryptoxanthin, Xyloglucan, Carotenoids, β-sitosterol Root : Resin, Alkaloids, Starch, Fatty Acids, Carbonic acid, Triterpenoid, Saponin Coccinoside, Flavonoid Glycoside, Lupeol, β-amyrin, β-sitosterol, Taraxerol 41||Antibacterial, antihelmintic,antioxidant, anti-inflammatory, antimalarial, antioxidant,
antipyretic, analgesic, antiulcer, hypoglycemic, antitussive,
antifungal, hepatoprotective, Antidyslipidemic, mutagenic,
alpha amylase inhibition41
|15||Tribulus terristris||Gokharu||saponins, flavonoids, glycosides,alkaloids, and tannins42||Diuretic, aphrodisiac, antiurolithic activity, immunomodulatory, antidiabetic, absorbtion enhancer, hypolypidemic, hepatoprotective, antiinflammatory, antispasmodic, anticancer, antibacterial, larvicidal, anticarciogenic, antistress43|
|16||Glycyrrhiza glabra||Liquorice||Glycyrrhizin, glucose, sucrose, mannite, starch, asparagine, resins ,formononetin; glabrone, neoliquiritin and hispaglabridin A & B.44||Antibacterial, antioxidant,antimalarial, antifungal,
antiviral, immunostimulatory spasmolytic, antiulcer, anti-arthritic ,
anti-inflammatory, antiallergic, demulcent, emollient, estrogenic, expectorant, laxative, anti carcinogenic45
|17||Bacopa monniera||Brahmi||Bacosides, bacopasides I–XII, brahmine, nicotine, and herpestine,46bacoside A3, bacopacide II, bacopasaponin C, bacosaponin C.47||Antiageing, antitoxin, Antioxidant, antistress48|
|18||Piper methysticum||Kava-kava||Root: chalcones, flavokavain A,flavokavain B, and flavokavain pipermethystine.49||CNS activity, antioxidant,anxiolytic, analgesic,
|19||Hypericum perforatum||St.John’s Wort||Napthaquinone hypericin, pseudohypericin,flavonoids, kaemferol, luteolin 51||Antidepressant, anxiolytic, diuretic, antimalarial, antihelmintic51|
|Curcuma longa||Turmeric||flavonoid curcumin , volatile oils(tumerone, atlantone, and zingiberone),
sugars, proteins, and resins.52
|Antioxidant, hepatoprotective,ant-inflammatory, anticarcinogenic, antimicrobial, cardiovascular, gastrointestinal, immunomodulatory52|
Natural therapies to reduce stress:
Mind-body medicine has also been shown to reduce stress and enhance well-being .These mind-body techniques help change the way individuals think about the problem, which gives them more control over their responses made to the stress. This enables individuals to manage and even reduce their stress because they are able to assert control over their reactions and behaviors to the stress.53 In addition, when individuals realize their ability to control their behaviors and, more importantly, their attitudes, they have more control over their stress overall. It becomes essential for individuals to learn how to control their thoughts, attitudes, and behaviours when encountering stressful situations. Following are some natural therapies to reduce stress.
- Relaxation techniques
- Division of labor
- Alcohol and drugs
- Time management
- Seek professional help
Herbal medicines are being used by about 80% of the world population primarily in the developing countries for primary health care. They have stood the test of time for their safety, efficacy, cultural acceptability and lesser side effects. The chemical constituents present in them are a part of the physiological functions of living flora and hence they are believed to have better compatibility with the human body.54
Herbal plants are the main source of medicine. Two of the largest users of medicinal plants are China and India. Traditional Chinese Medicine uses over 5000 plant species; India uses about 7000. According to Export-Import Bank, the international market for medicinal plant related trade having a growth rate of 7% per annum. China’s share in world herbal market is US$ 6 billion while India’s share is only US$1 billion. India exports crude drugs mainly to developed countries viz. USA, Germany, France, Switzerland, UK and Japan. There is an enormous scope for India also to emerge as a major player in the global herbal product based medicine.55
CONCLUSION: Plants have been used since prehistoric times for treatment of various ailments. In this review, the few herbal plants have been discussed which are previously explored by the various researchers for their antistress activity. It can be concluded that in the heart of the nature there are still so many plants, that have potent anti stress activity, and their utilities in current scenario need to be unveiled, so that they can also be used as herbal medication for betterment of human being. Ayurveda and modern medicine techniques must be coupled in order to bring out high quality herbal antistress products with rapid onset of action and good bioavailability. Further new research in the field of stress reveals a close relationship between emotional and nervous processes and the immune system.
AKNOWLEDGEMENT: The authors express their sincere thanks to Prof. (Dr.) H. H. Siddiqui, Dean Faculty of Pharmacy, Integral University, Lucknow, India for giving all encouragement and valuable support. The help render by Ms Barnali Bose, senior instructor is greatly appreciated.
- Desai S K, Desai S M, Navdeep S, et al., Antistress activity of Boerhaavia diffusa root extract and a polyherbal formulation containing Boerhaavia diffusa using cold restraint stress model. International Journal of Pharmacy and Pharmaceutical Sciences, 2011; 3(1):130-132.
- Ravindran R, Devi SR, Samson J etal., Noise‐Stress‐Induced Brain Neurotransmitter Changes and the Effect of Ocimum sanctum (Linn) Treatment in Albino Rats. Journal of Pharmacological Sciences, 2005; 98: 354-360.
- Verma N and Khosa R L, Effect of Costus speciosus and Wedelia chinensis on Brain Neurotransmitters and Enzyme Monoamine Oxidase Following Cold Immobilization Stress. Journal of Pharmaceutical Sciences and Research, 2009; 1(2): 22‐25.
- Umukoro S and Ashorobi R, Anti-Stress Potential of Aqueous Seed Extract of Aframomum Melegueta. African Journal of Biomedical Research, 2005; 8: 119 -121
- Tripathy H, Krishnan and S T, Lakshmana M et al., Effectiveness of spirulina in sound stress induced biochemical changes in rats. International Bulletin of Drug Research, 2011;1(1): 32-40.
- Sutanto W and E R Kloet, The use of various animal models in the study of stress and stress-related phenomena .Laboratory Animals (1994) 28, 293-306.
- Pawar S, Hugar S, A current status of adaptogens: natural remedy to stress. Asian Pacific Journal of Tropical Disease, 2012; S480-S490.
- Srikumar R, Parthasarathy N J, Rathinasamy S D, Immunomodulatory Activity of Triphala on Neutrophil Functions, Biol. Pharm. Bull.2005; 28(8): 1398—1403
- Sarris J, Panossian A, Schweitzer I et al., Herbal Medicine in Depression, Anxiety and Insomnia: A Review of Psychopharmacology and Clinical Evidence, 1-38.
- Madeline M Lorentz RN, Stress and Psychoneuroimmunology Revisited: Using mind -body interventions to reduce stress .Alternative Journal of Nursing July 2006, 11:1-11.
- http://www.oreilly.com/onconurse/factsheets/stress_immune.pdf (assesed on 7 march 2015)
- Mishra G, Singh P, Verma R et al, Traditional uses phytochemistry and pharmacological properties of Morienga oliefera plant: An overview, Scholar research library. Der pharmacia letter 2011, 3(2):141-164.
- Bandara B M R., Kumar N S, Wimalasiri K M S, Constituents of stem bark from Butea monosperma (leguminosae). J Natn Sci Coun Sri lanka, 1990; 18(2): 97-103.
- Gupta P, Chauhan N S, Pande Milind , Pathak , A Phytochemical and pharmacological review on Butea monosperma (Palash) International journal of Agronomy and Plant Production, 2012; 3 (7): 255-258.
- Ramachandran S, Sridhar Y, Sam S K, et.al , Aphrodisiac activity of Butea frondosa Koen. ex Roxb. extract in male rats. Phytomedicine. 2004; 11(2-3):165-168
- Deshmukh M, Sahare KN, Patidar RK, Mahajan B and Singh V, Antifilarial activity of Butea monosperma L. leaves extracts against Setaria cervi , Bhatwadekar A D, Chintawar S D, Logade N A, et al., Antistress activity of Butea monosperma flowers, Indian Journal of Pharmacology 1999; 31: 153-155
- Dixit P, Prakash T, Karki R, Kotresha D, Anti-obese activity of Butea monosperma (Lam) bark in experimentally induced obese rats. Indian journal of exp bio, 2012; 50(7):476-483.
- Venkatesh P , Rao M, Gobinath M, Umadevi G et al., A review on anti-stress activity of medicinal drugs from herbal sources. Journal of pharmaceutical research and development, 2011; 1(1):1-11.
- Warrier P.K, Indian Medicinal Plants, a compendium of 500 species, Orient Longman pvt.ltd, ed.4th, 2003,1:58.
- Singh B, and Rastogi R P, A reinvestigation of the triterpenes of Centella Asiatica. Phytochemistry, 1969; 8: 917-921.
- Singh B and Rastogi R P, Chemical examination of Centalla Asiatica Linn - III. Constitution of brahmic acid. Phytochemistry, 1968; 7: 1385-1393.
- Lindley J, Flora Medica. Pbl. Ajay Book Service, New Delhi, India. 1985, 198.
- Singh U Wadhwani A M and Johri B M, Dictionary of Economical Plants of India. Pbl. Indian Council of Agricultural Research, New Delhi, India. 1996, 46.
- Yingguang S, Yingfeng D, Yong L, Chang L et al., Simultaneous determination of nine components in Anemarrhena asphodeloides by liquid chromatography-tandem mass spectrometry combined with chemometric techniques, Journal of Separation Science, 2012;35(14):1796-1807.
- Marc T, Johnson J and Agrawal A A , Covariation and composition of arthropod species across plant genotypes of evening primrose, Oenothera biennis,2007;116: 941-956.
- Singh S, Kuar R, Sharma S R, An updated review on the oenothera genus, Journal of Chinese integrative medicine; 2012, 10(7).
- Mayank A, Panchal, Murti K, Lambole V,Pharmacological properties of Verbascum thapsus :A review. International Journal of Pharmaceutical Sciences Review and Research, 2010; 5 (2): 73-78.
- Chaudhary N, Husain S S, Ali M ,New Phenolic, triterpenic and steroidal constituents from the fruits of Cuminum cyminum L. Journal of pharmacognosy and phytochemistry, 2014;3 (1):149-154.
- Koppula S, Choi D K, Cuminum cyminum extract attenuates scopolamine-induced memory loss and stress-induced urinary biochemical changes in rats: a noninvasive biochemical approach. Pharm Biol. 2011; 49(7):702-708.
- Sayyah M , Peirovi A and Kamalinejad M, Anti-Nociceptive Effect of the Fruit Essential Oil of Cuminum cyminum L. in Rat, Iranian Biomedical Journal ,2002;6 (4): 141-145
- Kumar A, Kumar R, Kumar N, Nath A, et al., Protective Effect of Cuminum cyminum and Coriandrum sativum on Profenofos Induced Liver Toxicity. International Journal of Pharmaceutical & Biological Archives, 2011; 2(5):1405-1409.
- Bhat S P, Rizvi W, Kumar A, Effect of Cuminum cyminum L. Seed Extracts on Pain and Inflammation. Journal of Natural remedies, 2014; 14(2):187-192.
- Shi C, Liu J, Wu F and D T Yew ,Review Ginkgo biloba Extract in Alzheimer’s Disease: From Action Mechanisms to Medical Practice , International Journal of Molecular Sciences, 2010, 11, 107-123.
- Mahadevan S, and Park Y, Multifaceted Therapeutic Benefits of Ginkgo biloba L.: Chemistry, Efficacy, Safety, and Uses, 2008; 73( 1)
- Nayeem, Khatun A, Rahman M S and Rahman M, Evaluation of phytochemical and pharmacological properties of Mikania cordata (Asteraceae) leaves. Journal of Pharmacognosy and Phytotherapy, 2011; Vol. 3(X) : XX-XX
- Luciane C, Rufatto, GowerA, SchwambachJ et al., Genus Mikania: chemical composition and phytotherapeutical activity. Revista Brasileira de Farmacognosia 2012,22(6)
- P R, Kamdod M A, Emblica officinalis (Amla): A review of potential therapeutic applications, International journal of green pharmacy, 2012; 6(4):257-269.
- Edema M O, Osarumwense O P, Preliminary Studies on the Phytochemical and Pharmacological Screening of Alchornea Cordifolia, Nigerian journal of chemical research,2007; vol.12
- Lamikanra A, Ogundaini AO and OgungbamilaFO, Antibacterial constituents of Alchornea cordifolia leaves, Phytotherapy research, 1990; 4(5) : 198–200.
- Pekamwar S S, Kalyankar T M, and Kokate SS, Pharmacological Activities of Coccinia Grandis: Review, Journal of Applied Pharmaceutical Science, 2013; 3 (05):114-119
- Usman H, Abdulrahman F, Ladan A. Phytochemical and antimicrobial evaluation of Tribulus terrestris L. growing in Nigeria. Res J Biol Sci. 2007; 2:244–7.
- Chhatre S, Nesari T, Somani G, Kanchan D et al., Phytopharmacological overview of Tribulus terrestris, Pharmacogn Rev, 2007; 2:244–247
- Houseman, loc. cit.; Thorpe, VII, 362; Kapur et. al., loc. cit.; Trease, 393; McIlroy, 40; Puri & Seshadri, J. sci. industr. Res., 1954, 13B, 475; Chem. Abstr., 1950, 44, 4635.
- Gujral M L, Sareen K, Phukan D P and Amma, M K P, Anti-arthritic activity of glycyrrhizin in adrenalectomised rats. Indian J. Med. Sci. 1961; 15: 625.
- Sivaramakrishna C, Rao C V, Trimurtulu G, Vanisree M, et al., Triterpenoid glycosides from Bacopa monnieri. Phytochemistry 2005; 66:2719–2728.
- Garai S, Mahato S B, Ohtani K, Yamasaki K. Dammarane triterpenoid saponins from Bacopa monnieri. Can J Chem 2009; 87:1230–1234.
- Chakravarty A K, Garai S , Masuda K, Nakane T, Kawahara N. Bacopasides III–V: Three new triterpenoid glycosides from Bacopa monniera. Chem Pharm Bull 2003; 51:215–217.
- Selvan A , Ravali R, Suthakaran R , Prithvi S, Ravinootala et al., Effect of Piper methysticum root on CNS activity, Journal of Pharmacy Phytotherapeutics, 2013; 1:4
- Estrada R, Laurrabaquio A M , Suárez U D and Escalona AG , Neuropharmacological studies of Piper auritum Kunth (Piperaceae): antinociceptive and anxiolytic-like effects ,2013;7(23) 1718-1729.
- Dhingra D and Sharma A, A review on anti-depressants plants , Natural products Radiance, 2005,144-152
- Akram M , Shahab-uddin , Ahmed A , khan U ,et al., Curcuma longa and Curcumin: a review article. Journal biology – plant biology, 2010; 55(2): 65–70.
- Ashok D B Vaidya ,The status and scope of Indian Medicinal plants acting on Central Nervous System, Indian journal of Pharmacology ,1997; 29: 340-343
- Sharma A, Shanker, Tyagi L K , Singh M et al.,Herbal Medicine for Market Potential in India: An Overview, Academic Journal of Plant Sciences, 2008 ;1 (2): 26-36.
- Wahab S, Hussain A, Ahamd P and Rizvi A, Current Status of Herbal Drugs in the Development of Newer Therapeutics Agents, International Journal of pharmaceutical and chemical sciences, 2013; 2(3):1462-1473.
How to cite this article:
Rizvi A, Mishra A, Mahdi AA, Mohd Ahmad and Basit A: Natural and Herbal Stress Remedies: A Review. Int J Pharmacognosy 2015; 2(4): 155-60:.doi link: http://dx.doi.org/10.13040/IJPSR.0975-8232.IJP.2(4).155-60.
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Ankit Chokriwal, Madan Mohan Sharma and Abhijeet Singh*
Department of Biosciences, Manipal University, Jaipur, Rajasthan, India
26 January, 2015
21 March, 2015
29 March, 2015
01 April, 2015