CHANGE IN SERUM FREE FATTY ACID (FFA) LEVEL ASSOCIATED WITH DM TYPE-II IN OBESE PERSONAbstract
Introduction: Obesity is associated with DM Type-II. The major basis for the association between these two is the ability of obesity to engender insulin resistance. Insulin resistance is a fundamental aspect of etiology of DM Type-II. Different factors increase insulin resistance, but FFA is the most common factor to increase insulin resistance. Aims and Objectives: Most of the obese person (80%) is DM Type-II, but all obese are not diabetic, why? To study the FFA level in obese without DM Type-II verses obese with DM Type-II subjects. Materials and Methods: Subjects were taken from OPD & IPD, Department of Medicine, SRMS, IMS Bareilly (U.P.) India, of both sexes, coming from reasonable distances around Bareilly city. They were from the lower and middle class of rural area having moderate physical activities, with vegetarian as well as non-vegetarian dietary habits and were obese as per new Asian BMI guidelines and have symptoms of diabetes. Subjects were not on any drug treatment before taken blood sample. Serum FFA level estimated by ELISA method and blood sugar was estimated by GOD-POD method. Results and Conclusion: FFA level in obese without DM Type-II verses obese with DM Type-II were either normal or below normal, so we concluded that FFA level was not so much related with insulin resistance in our study group.
M. Gupta, Ziledar and N. Yadav
Department of Biochemistry, SRMS, IMS, Bareilly, Uttar Pradesh, India.
19 July 2014
13 September 2014
29 September 2014
01, October 2014