PHYTOCHEMICAL STUDY AND EVALUATION OF WOUND HEALING POTENTIAL OF CRUDE LEAVE EXTRACTS OF OROXYLUM INDICUM (L.) VENT IN WISTAR RATS
The present study was carried out to evaluate the wound healing potential of different extracts of Oroxylum indicum leave in two different types of wound models in albino rats viz., incision and excision, and compare the effects with povidone iodine ointment which is used as standard drug. Among all the extract, the ethanolic extract at a dose of (250 mg/kg) possesses a significant increase in wou...
APPLICATIONS OF SURFACTANTS IN PHARMACEUTICAL FORMULATION DEVELOPMENT OF CONVENTIONAL AND ADVANCED DELIVERY SYSTEMS
The role of surfactants is very critical in the development of pharmaceutical formulations. The diverse applications in different delivery systems have been highlighted in different reports of formulation development for various conventional and advanced delivery systems. The relevancy of critical micelle concentration and HLB value for the section of surfactants for different drug delivery system...
Natural products are an important source of bioactive compounds and have potential for the development of novel therapeutics. Natural products and their derivatives represent more than 50% of all drugs in clinical use in the world. Herbal plants contain and produce a verity of chemical substances used as a remedy for treating diseases. Anthelmintic and antioxidants have been treated with some medi...
The present study was undertaken to develop gluten-free biscuits from the processed composite flour. Composite flour was prepared using teff millet flour (TF), navy bean flour (NF), and watermelon seeds flour (WF). Three variation were formulated such as, A (TF: NF: WF = 45:45:10), B (TF: NF: WF = 55:35:10), C (TF: NF: WF = 65:25:10) respectively. These biscuits were evaluated for rheological prop...
HUMAN GLUTATHIONE S-TRANSFERASE A1-1 BINDING WITH NATURALLY OCCURRING LIGANDS: ASSESSMENT BY DOCKING SIMULATIONS
Glutathione S-transferases are phase-II enzymes associated with detoxification and resistance to drugs and xenobiotics. The majority of human tumors and human tumor cell lines express significant amounts of alpha class Glutathione S-Transferase A1-1. Present study aimed to examine hGSTA1-1 interaction with some naturally occurring ligands using docking simulations. Docking simulation using Glutath...
Calotropis gigantea, belonging to the family of Asclepiadaceae. The plant has the antimicrobial activity, antioxidant activity, analgesic activity, anti-pyretic activity, insecticidal activity, cytotoxicity activity, hepatoprotective activity, purgative properties and wound healing activity. The present paper is an attempt to provide a detailed botanical description, classification, phytochemical ...
ANTIOXIDANT ACTIVITY BY DPPH RADICAL SCAVENGING METHOD OF METHANOLIC EXTRACT OF N- BUTANOL FRACTRION OF TRIBULUS TERRESTRIS LINN. (FAMILY ZYGOPHYLLACEAE)
In this study antioxidant activity was performed by DPPH (1,1 diphenyl-2-picrylhydrazyl) radical scavenging method for Tribulus terrestris L. whole plant methanolic extraction fractionation with toluene and n-butanol in succession. The obtained fractions were concentrated under reduced pressure to yield corresponding antioxidant activity. The IC50 concentration for the standard, ascorbic acid and ...
COMPARATIVE STUDY OF THE EFFECTS OF DILTIAZEM VERSUS ALPHA TOCOPHEROL ON RETINAL DEGENATION IN RABBITS
Disturbance in retinal blood supply can have an effect on the supply of oxygen and the substrates which leads to retinal ischemia, the result is irreversible, ischemic and apoptotic cascades resulting in cell death. The present study was conducted to study the protective effects of diltiazem and vitamin E "alpha-tocopherol," against degenerative ischaemic retinal changes induced by Middle Cerebral...
CHEMICAL CONSTITUENTS AND TYROSINASE INHIBITORY ACTIVITY OF AQUEOUS FRACTION OF THE LEAVES OF MORUS ALBA LINN. FROM VIETNAM
The mulberry has been widely cultivated to feed silkworms. The leaves of mulberry have been used in traditional medicine as an analgesic, antitussive, cathartic, diuretic. In this study, we have isolated three compounds (LC1-3) by chromatographic methods from the mulberry leaves (Morus alba L.) collected in Thai Nguyen province, Vietnam. These compounds were identified as Kaempferol-3, 7-di-O-α-L...
Baccaurea ramiflora Lour., syn. Baccaurea sapida (Roxb.) Muell. Arg. known as Burmese grapes belongs to the family Euphorbiaceae and is native to Southeast Asia. The observance on Baccaurea ramiflora leads that this plant is utilized as an antichloristic and anodyne against rheumatoid arthritis, abscesses, cellulitis and treat injuries. This plant also has anti-diarrheal, analgesic, anti-inflammat...