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SYNTHESIS, CHARACTERIZATION & BIOLOGICAL EVALUATION OF SOME AZETIDINE DERIVATIVES
New series of N-(3-chloro-2-oxo-4-substituted-azetidine-1-yl) 2-methyl-1H-indole-3-carboxamide derivatives (VIa-d) were prepared and tested for their antibacterial and antifungal activity. The synthesis is based on the condensation of phenylhydrazine and ethyl acetoacetate in the presence of acetic acid to ethyl (2-methyl-1H- indol-3-yl)-2-oxoacetate (III) which on reaction with hydrazine hydrate ...
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IN-VIVO STUDY OF ANTILITHIATIC ACTIVITY ON THE FRUITS EXTRACTS OF COCCINIA INDICA (WIGHT & ARN.) ETHYLENE GLYCOL INDUCED LITHIATIC IN RATS
Aim of the Study: This study aimed to investigate the effect of ethanolic extract of fruits Coccinia indica Wight & Arn. (Cucurbitaceae) on urolithiasis in rats. Materials & methods: Thirty-six male rats were randomly divided into six groups (n = 6). Ethylene glycol (EG) 0.75% in drinking water were fed to all groups (Groups II-VI) except normal control (Group I) rats for 15-28th days to i...
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HEPATOPROTECTIVE ACTIVITY OF ETHANOLIC EXTRACT FROM THE STEM BARK OF SYNEDRELLA NODIFLORA ON CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY IN SWISS ALBINO RATS
The ethanol extracts of stem bark of Synedrella nodiflora belonging to the family of Asteraceae was studied for hepatoprotective activity against Swiss Albino Rats with liver damage induced by carbon tetrachloride (CCl4). It was found that the ethanol extract of Synedrella nodiflora at a dose of 250 mg/kg body weight exhibited significant protective effect by lowering the serum level of alanine am...
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EVALUATION OF DAMAGE CAUSED BY BRUCHUS PISORUM L. ON SOME PARAMETERS RELATED TO SEED QUALITY OF PEA CULTIVARS
It was evaluated the damage caused by Bruchus pisorum on the germination ability of pea forage cultivars. Result of damage in seeds with parasitized larva was significant decrease of the germination by 16.4% percentage points, the length and weight of primary radicle by 16.8 and 24.5%, the length and weight of plumule by 12.3 and 14.1%, the vigor index of primary radicle and plumule by 32.5 and 32...
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EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF SYZIGIUM ALTERNIFOLIUM (WIGHT) WALP.
Ethanol extract from the stem bark of Syzygium alternifolium exhibited significant activity against thioacetamide toxicity in rats. Glutamic oxaloacetic transaminase, alkaline phosphatase, total bilirubin, total cholesterol, lactate dehydrogenase, and total protein in serum indicated the hepatoprotective effect of the ethanol extract. Histopathological examination of liver sections confirmed that ...
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PHYTOCHEMICAL ANALYSIS AND ANTIOXIDANT PROPERTY OF PREMNA LATIFOLIA
Plants have been used for centuries as a remedy for human diseases because they contain phytochemical components of therapeutic values. Hexane, ethyl acetate and ethanolic extract of Premna latifolia were investigated for phytochemical constituent and antioxidant activity. The phytochemical constituent was investigated using standard chemical methods. Further, the study was extended by analyzing t...
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THE STUDY EFFECT OF HYDRO-ALCOHOLIC EXTRACT OF JAPANESE PERSIMMON FRUIT ON FORMALIN-INDUCED INFLAMMATION IN THE RAT
Acute and chronic inflammation is the most important issue in the field of health. Also, due to the side effects of synthetic drugs, herbal products are widely used in the control of inflammation. In this study was investigated the effect of a hydro-alcoholic extract of Japanese persimmon fruit on the formalin-induced inflammation in the rat paw. 30 male Wistar rats were divided into 5 groups: neg...
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ANTIMICROBIAL ACTIVITY OF METHANOLIC EXTRACT OFCISSUS PALLIDA
Herbs have been widely used for centuries as remedies for diseased human conditions as they have certain phytochemicals of diseases curing nature. The present study explains the antimicrobial (antibacterial & antifungal) potential of dried stem wood of Cissuspallida methanolic extract against bacterial strains of Bacillus subtilis, Klebsiella pneumonia, Staphylococcus aureus, Escherichia coli,...
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PHARMACOGNOSTIC STUDIES OF STEM TUBER ON BRASSICA OLERACEA VAR. GONGYLODES
The crude extracts from stem tuber and leaf of Brassica oleracea var. gongylodes in different solvents, were subjected to physicochemical, fluorescence analysis, phytochemical and antimicrobial study. The microscopic analysis revealed that B. oleracea showed stone cells and calcium oxalate prisms. The ash value was high 7.88 % in B. Oleracea. The fluorescent analysis at 366 nm of B. oleracea under...
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PHARMACOGNOSTICAL STUDIES ON TRAGIA PLUKENETTI R. SMITH
The global market for herbal products is exploding. The major hindrance in the amalgamation of herbal medicines into modern medical practices is the lack of scientific and clinical data and a better understanding of efficacy and safety of the herbal products. The evaluation or standardization of a crude drug involves Pharmacognostic methods such as organological, physicochemical, phytochemical and...
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