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ISSN (Online): 2348-3962,
ISSN (Print): 2394-5583

International Journal Of Pharmacognosy

An International Journal published monthly
ICV (2015): 69.75, Projected Impact Factor (2017) : 0.59
DOI: 10.13040/IJPSR.0975-8232.IJP

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Posted by on Sep 4, 2008 in Blog | 0 comments

ANTIOXIDANT EFFECT OF CRUDE WATER EXTRACT OF VETIVERIA ZIZANIOIDES (GRAMINEAE) IN MICE WITH ACETAMINOPHEN INDUCED HEPATOTOXICITY

ANTIOXIDANT EFFECT OF CRUDE WATER EXTRACT OF VETIVERIA ZIZANIOIDES (GRAMINEAE) IN MICE WITH ACETAMINOPHEN INDUCED HEPATOTOXICITY

Acetaminophen (APAP) is widely used as an analgesic and antipyretic drug. Large dose of APAP results in severe hepatic necrosis due to the oxidative stress. This work evaluates the antioxidant activity of crude water extract of Vetiveria zizanioides rootsagainst a single dose of APAP induced acute hepatotoxicity. Mice were treated with 300 mg/kg of APAP dissolved in saline and fasted for 16h. N-Acetylcysteine (NAC, 500 mg/kg) was used as a positive control. The activities of serum alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP) increased significantly 4 h after APAP administration. Oral administration of crude water extract of Vetiveria root at a dose of 0.9 g/kg before or after the oral administration of APAP significantly reduced (P<0.05) the elevated values of serum ALT, AST, ALP and hepatic morphologic changes induced in mice. Antioxidant status, reduced glutathione (GSH), glutathione reductase (GR) and glutathione S-transferase (GST) were reduced significantly (P<0.05) and the lipid peroxidation and the activity of GPx were enhanced significantly in the APAP treated group. Vetiveria root...

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Posted by on Aug 5, 2008 in Blog | 0 comments

SYNTHESIS OF SOME NEW ANTIMICROBIAL 5,6,7,8-TETRAHYDROPYRIMIDO [4,5-b] QUINOLONE DERIVATIVES

SYNTHESIS OF SOME NEW ANTIMICROBIAL 5,6,7,8-TETRAHYDROPYRIMIDO [4,5-b] QUINOLONE DERIVATIVES

2-Amino-1-aryl-1,4,5,6,7,8-hexahydro-4-phenylquinoline-3-carbonitrile derivatives were synthesized by the reaction of cyclohexanone (1) with 2-benzylidinemalononitrile (2) and the appropriate of aniline derivatives. The reactivity of some of these newly synthesized derivatives toward carbon disulfide and further toward hydrazonoyl halides were also studied. In addition, the antimicrobial activity of the newly synthesized derivatives was...

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Posted by on Aug 5, 2008 in Blog | 0 comments

ANTIMICROBIAL ACTIVITY OF LAGENARIA SICERARIA CRUDE EXTRACT OBTAINED FROM ITS FLOWERS

ANTIMICROBIAL ACTIVITY OF LAGENARIA SICERARIA CRUDE EXTRACT OBTAINED FROM ITS FLOWERS

Many herbal remedies have been employed in various medical systems for the treatment and management of different diseases. The plant Lagenaria siceraria, a plant belonging to the family Cucurbitaceae, has been used in different system of traditional medication for the treatment of diseases and ailments of human beings. The n- hexane extract of Lagenaria siceraria was screened for antimicrobial activity against a wide range of both gram-positive and gram-negative bacteria by disc diffusion method. The results obtained were compared with that of a standard antibiotic, kanamycin. The n-hexane extract showed significant antimicrobial activity against Escherichia coli (17.25mm), and Salmonella typhi (17.80 mm). But there was no antimicrobial activity against Vibrio cholera, Bacillus cereus, Bacillus subtilis and Staphylococcus...

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Posted by on Aug 5, 2008 in Blog | 0 comments

Etiam placerat ipsum porttitor ipsum

Etiam placerat ipsum porttitor ipsum

Mauris faucibus velit ac lorem. Aliquam auctor laoreet erat. Phasellus luctus odio nec risus. Cum sociis natoque penatibus et magnis dis parturient montes, nascetur ridiculus mus. Quisque malesuada auctor nisl. Fusce non neque. Donec diam lorem, pharetra non, pulvinar id, luctus vel, urna. Nam suscipit, ipsum vitae tincidunt laoreet, enim dolor rhoncus ante, et consequat lorem purus eleifend risus. Vestibulum sit amet leo in purus fringilla laoreet. In hac habitasse platea dictumst. Sed leo. Maecenas iaculis vestibulum lorem. Etiam placerat ipsum porttitor ipsum. Ut sit amet nulla. Curabitur et leo. Nulla suscipit, eros non fermentum sollicitudin, justo purus consectetuer ante, in viverra ante lacus at nisl. Sed ac lectus. Mauris dui elit, sodales ac, tempor non, tristique in, ipsum. Sed viverra nulla et lectus. Curabitur urna. Mauris a eros et libero pretium dictum. Vivamus volutpat nisi sit amet nunc. Vivamus semper tellus sed felis luctus dictum. Integer lacus purus, lacinia quis, pulvinar vel, consequat nec, metus.Nullam ac erat. Donec a ipsum. Nullam tristique leo id lacus. Sed sed pede...

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Posted by on Jul 17, 2008 in Blog | 0 comments

Urna eget erat non purus

Urna eget erat non purus

Suspendisse aliquet sem ut nulla. Cras mollis ornare nisl. Morbi ac mi. Nunc eget nisi. Donec at enim. Pellentesque habitant morbi tristique senectus et netus et malesuada fames ac turpis egestas. Sed diam. Ut sagittis ultrices urna. Suspendisse eget erat non purus varius sodales. Aliquam imperdiet lobortis libero. Suspendisse scelerisque sagittis odio. Phasellus imperdiet interdum dolor. Mauris ante ante, gravida at, consectetuer quis, ullamcorper ornare, magna. Duis sed mauris sed libero tincidunt rutrum. In vulputate pretium dolor.Nullam ac erat. Donec a ipsum. Nullam tristique leo id lacus. Sed sed pede non arcu ornare interdum. Maecenas justo elit, rutrum in, adipiscing id, laoreet in, libero. Fusce quam. Donec a urna a enim gravida dictum. Nunc elementum, mauris sit amet imperdiet iaculis, dolor metus consectetuer mi, et tempor elit enim at massa. Duis ac nisl. Nullam pulvinar. Curabitur quam sapien, lobortis eu, luctus vitae, volutpat ac, metus. Nam elementum. Fusce fringilla. Praesent pulvinar turpis vitae justo cursus pulvinar. In hac habitasse platea dictumst. Nunc fermentum tellus interdum libero. Phasellus eros. Vestibulum...

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Posted by on Jan 27, 2008 in Blog | 0 comments

Vestibulum eu dui eget diam

Vestibulum eu dui eget diam

Lorem ipsum dolor sit amet, consectetuer adipiscing elit. Sed pede felis, tempor eu, aliquet ut, pulvinar eu, nunc. Quisque sed magna non risus porta sollicitudin. Morbi congue sapien nec diam. Cras nibh lacus, ullamcorper sit amet, pretium congue, consectetuer convallis, metus. Aliquam erat volutpat. Cum sociis natoque penatibus et magnis dis parturient montes, nascetur ridiculus mus. Class aptent taciti sociosqu ad litora torquent per conubia nostra, per inceptos himenaeos. Maecenas tincidunt justo sed dolor.Nullam ac erat. Donec a ipsum. Nullam tristique leo id lacus. Sed sed pede non arcu ornare interdum. Maecenas justo elit, rutrum in, adipiscing id, laoreet in, libero. Fusce quam. Donec a urna a enim gravida dictum. Nunc elementum, mauris sit amet imperdiet iaculis, dolor metus consectetuer mi, et tempor elit enim at massa. Duis ac nisl. Nullam pulvinar. Curabitur quam sapien, lobortis eu, luctus vitae, volutpat ac, metus. Nam elementum. Fusce fringilla. Praesent pulvinar turpis vitae justo cursus pulvinar. In hac habitasse platea dictumst. Nunc fermentum tellus interdum libero. Phasellus eros. Vestibulum euismod nunc at...

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