REGULATION OF WNT GENES IN STEM CELLS DEVELOPMENT AND ORGANOGENESIS
AbstractStem cell biology, many signals regulated stem cells and organ development. Wnt factors play a crucial role in stem cells development and induced signaling pathway in stem cells. Wnt signals classified as a canonical and non-canonical pathway. Wnt factors regulated both pathways for stem cells self-renewal, proliferation, and differentiation. Wnt canonical pathway induced by Wnt1, Wnt2, Wnt2b, Wnt3, Wnt3a, Wnt4, Wnt5a, Wnt6, Wnt7a, Wnt7b, Wnt8a, Wnt8b, Wnt10a and Wnt10b. Wnt non-canonical pathway regulated by Wnt factors such as Wnt1, Wnt4, Wnt5a, Wnt5b, Wnt6, Wnt7a, Wnt7b, Wnt9a, Wnt9b, Wnt10a, Wnt10b, Wnt11, and Wnt16. These all factors have a specialized role in stem cells and development. These factors also regulated wound healing mechanism and variety of organ regeneration. Finally, abnormality or aberrant expression of Wnt signals regulated a variety of cancers
Article Information
2
366-372
688
1390
English
IJP
R. Prakash
Department of Biotechnology, VMKV Engineering College, Vinayaka Missions University, Salem, Tamil Nadu, India
yokaprakash0007@gmail.com
20 April 2014
23 May 2014
28 May 2014
http://dx.doi.org/10.13040/IJPSR.0975-8232.1(6).366-372
01 June 2014