PHYTOCHEMISTRY AND PHARMACOLOGICAL PROPERTIES OF GYMNEMA SYLVESTRE (ASCLEPIADACEAE): A REVIEWHTML Full Text
PHYTOCHEMISTRY AND PHARMACOLOGICAL PROPERTIES OF GYMNEMA SYLVESTRE (ASCLEPIADACEAE): A REVIEW
Pritesh Ranjan Dash * 1, Shishir Ahmed Sikta 2, Jerin Mahbub 3, Feona Shermin 2 and Farjana Islam 4
Department of Pharmacy 1, Jahangirnagar University, Savar, Dhaka, Bangladesh.
Department of Pharmaceutical Sciences 2, North South University, Dhaka, Bangladesh.
Department of Pharmacy 3, BRAC University, Mohakhali, Dhaka, Bangladesh.
Department of Pharmacy 4, East West University, Dhaka, Bangladesh.
ABSTRACT: Gymnema sylvestre, is a traditional medicinal plant, belonging to the family of Asclepiadaceae; commonly distributed throughout the world, predominantly in tropical regions. The plant exhibits a broad range of therapeutic effects as an effective natural remedy for diabetes, dyspepsia, helminthiasis, constipation, hemorrhoids, jaundice, cardiopathy, asthma, bronchitis, leucoderma and several inflammatory diseases. Gymnemic acid, the active compound of this plant is significantly related with obesity and diabetes in order to control them in a positive way. Additionally, some of the potential pharmacological activities such as antimicrobial, antihyphal, anti-hyper-cholesterolemic, and hepatoprotective activities of the plant were also reported. Pre-eminently, the aim of this review is to explore the transition of a traditional therapeutic to a modern contemporary medication with an overview of phytochemistry and pharmacological activities of the plant and its phyto-constituents.
Gymnema sylvestre, Phytochemistry, Pharmacological activities, Toxicity
INTRODUCTION: Plants have been used for therapeutic purposes from the ancient period. Various chemical compounds isolated from plants, have biological functions including defense action against different kinds of fungi, insects and herbivorous mammals. Some plants and their derivatives are also used as active ingredients in the formulation of different drugs like aspirin. Formulas for the treatment of basic illnesses, for example, diarrhea, constipation, low sperm count, hypertension, dysentery and weak penile erection, coated tongue, piles, bronchial asthma, menstrual disorders, leucorrhoea and fevers are given by the traditional medicine practitioners very effectively 1.
As of late, World Health Organization (WHO) assessed that 80% of individuals are now using herbal medicines as their primary health care needs. According to WHO, there are more than 21,000 plant species which have the efficiency to cure diseases and is being used as medicinal plants 2. Treatment with medicinal plants is viewed as extremely protected as there is no or negligible side effects.
Gymnema sylvestre is a medicinal plant belonging to the family Asclepiadaceae that grows extensively in Asia. It has been used in the treatment of diabetes for nearly two millennia and commonly known as gudmar. The plant has been reported to have antimicrobial, antioxidant and antiviral effects 3. It is also used for controlling obesity in the form of Gymnema tea. Secondary metabolites of the plant like alkaloids, terpenoids, phenolics, steroids and flavonoids play an important role in interaction of the plant with its environment. The amount and type of phytochemical compounds vary from plant to plant. In Gymnema species, phytochemicals such as saponins, terpenoids, flavonoids, tannins, steroids and alkaloids have anti-inflammatory effects. Saponins possess anti-diabetic and hypo-cholesterolemic properties. The terpenoids have also been shown to reduce blood glucose level in animal studies. The steroids and saponins affect the activity of central nervous system 4. The following is a comprehensive and up-to-date review about the distribution, phytochemistry and pharmacological properties of Gymnema sylvestre with an urge of further advancements in the medicinal uses of the herb worldwide.
Synonyms: Gymnema affine Decne, Gymnema alterniflorum (Lour.) Merr., Gymnema formosanum Schltr., Gymnema geminatum R.Br., Gymnema humile Decne., Gymnema mkenii Harv., Gymnema parvifolium Wall., Gymnema subvolubile Decne., Gymnema sylvestre var. affine (Decne.) Tsiang.
Vernacular Indian Names: Bengali: meshashrunga, Gujarati: gudmar, Hindi: gurmar, Malayalam: chakkarakolli, Marathi: beakichapala.
Super division: Spermatophyta
Genus: Gymnema R.Br.
Species: G. sylvestre
Gymnema sylvestre: G. sylvestre is a moderate developing, perpetual, woody climber, conveyed all through the India, in become backwoods scarce to 600 m tallness. Fundamentally it is amassed in the tropical timberland of Central and Southern India. Besides, it is found in Banda, Konkan, Western Ghats, Deccan stretching out to the parts of Western and Northern India 5.
The plant is an expansive, pretty much pubescent, woody climber. The leaves are inverse, normally elliptic or praise (1.25 - 2.0 inch × 0.5 - 1.25 inch). Blooms are little, yellow, in axillary and horizontal umbel in cymes; Follicles are terete and lanceolateupto 3 creeps long. The calyx-flaps are long, praise, insensitive and pubescent. Corolla is light yellow campanulate, valvate, crown single, with 5 plump scales. Scales adnate to throat of corolla tube between projections; another connective delivered into a memberanous tip, pollinia 2, erect, carpels 2, unilocular; locules numerous ovuled 6, 7.
FIG. 1: GYMNEMA SYLVESTRE
Gymnema sylvestre: The leaves of G. sylvestre contain triterpene saponin which belongs to oleanane and dammarene classes. Oleanane saponins are gymnemic acids and gymnema saponins, whereas dammarene saponins are gymnemasides 8. The leaves also contain resins, chlorophyll, albumin, tartaric acid, formic acid, carbohydrates, butyric acid, anthraquinone derivatives, organic acid (5.5%), parabin, inositole alkaloids, calcium oxalate (7.3%), lignin (4.8%) and cellulose (22%). A new flavonol glycoside named kaempferol 3-O-beta-D-glucopyranosyl- (1-->4)- alpha-L-rhamnopyranosyl- (1-->6) beta-D-galactopyranoside has also been found in aerial parts of G. sylvestre 9, 10. Additionally, three new oleanane type triterpene glycosides and four new triterpenoi saponins, gymnemasins; have been isolated from the leaves of G. sylvestre were identified as 3-O-[beta-D-glucopyranosyl(1-->3)-beta- d- lucuro-nopyranosyl] gymnemanol, 3-o-[beta- d glucopyranosyl (1-->3)- beta- d-gluco-pyranosyl]-22-O-tiglyolgymnemanol, 3-O-beta d glucuronopyranosyl-22-O-tigloylgymnemanol and 3- O- beta- D- glucopyranosyl gymnemanol respectively. Moreover, gymnestrogenin, a new penta hydroxytri terpene from the leaves of G. sylvestre has likewise been reported. Other plant constituents are anthraquinones, flavones, hentri-acontane, pentatriacontane, phytin resins, d-quercitol, α and β-chlorophylls, tartaric acid, formic acid, butyric acid, lupeol, β-amyrin related glycosides and stigmasterol. The plant extract also showed positive results for alkaloids 11.
FIG. 2: STRUCTURES OF SOME PHYTOCONSTITUENTS ISOLATED FROM GYMNEMA SYLVESTRE
Anti-diabetic Activity: The hypoglycemic activity of Gymnema sylvestre leaves was first reported in the late 1920s. The plant’s hypoglycemic activity is slow in nature, varying from the fast impact of numerous solutions hypoglycemic medications. Gymnema leaves raise insulin levels by causing recovery of β-cells in the pancreas that discharge insulin. Research has demonstrated that Gymnema enhances the take-up of glucose into cells by expanding the movement of glucose-using proteins, and keeping adrenaline from empowering the liver to deliver glucose, with the net impact that glucose levels are decreased. Another antidiabetic impact of Gymnema is that it nullifies the essence of sugar, which has the impact of smothering and killing the desire for desserts. Gymnemic corrosive found in the leaf extricates restrains hyperglycemia and furthermore goes about as a cardiovascular stimulant. Oral organization of a water dissolvable portion G-54 confined from Gymnema sylvestre directed to 27 sort 2 diabetic patients diminished their insulin prerequisite, brought down the fasting glucose and glycosylated hemoglobin content 12. Two water dissolvable portions (GS-3 and GS-4) acquired from leaves were found to twofold the pancreatic islets and β-cell numbers in diabetic rats 13.
Alcoholic leaf remove (500 mg/kg, orally) brought down most extreme glucose in fasted, glucose encouraged and diabetic rats alongside insulin discharged from pancreatic β-cells 14. In rats the insulin emission from islets of Langerhans and a few pancreatic β-cell lines initiated by alcoholic concentrate without different jolt 15. Gymnemic corrosive IV, disconnected from leaves created intense hypoglycemic impact in STZ-diabetic mice. Leaf separate has been seen to deliver against hyperglycemic 16 and hypoglycemic 17 impacts in corticosteroid-incited diabetes mellitus, without adjusted serum cortisol focus. A polyherbal detailing containing fluid concentrates of Gymnema sylvestre delivered conspicuous hypoglycemic movement in typical and diabetic rats at a dosage of 100 - 500 mg/kg/day, orally for intense, 6 h and for long haul, a month and a half investigation 18. Gymnemic corrosive IV secluded from the leaves has been seen to create hypoglycemic, hostile to hyperglycemic, glucose take-up inhibitory and gut glycosidase inhibitory impacts. G. sylvestre leaves separate likewise treated diabetic rats difficulties 25 including hyperglycemia, hypoinsulinemia, hyperlipidemia and oxidative anxiety 19. It also showed low inhibition of amylase activity, but showed maximum hindrance to the diffusion of glucose across the dialysis membrane and thus works as antidiabetic agent 20. According to 21, pretreatment with Gymnema sylvestre significantly prevented the development of insulin resistance and associated complications such as diabetes. Methanolic leaf extract of Gymnema sylvestre (30 mg/kg, orally) also showed significant anti-hyperglycemic effect on rats having diabetes mallitus 22.
Hypolipidemic Activity: Gymnema leaves are likewise noted for bringing down serum cholesterol and triglycerides. Gymnema leaf separate at a measurement of 25 - 100 mg/kg regulated orally to tentatively initiated hyperlipidemic rats for two weeks lessened the raised serum trigylceride, add up to cholesterol, low thickness lipoprotein and low thickness lipoprotein cholesterol in a dosage subordinate way. The capacity of the concentrate at 100 mg/kg to bring down triglycerides and aggregate cholesterol in serum and its hostile to antherosclerotic potential was like that of the standard lipid-bringing down operator clifibrate 23. G. sylvestre also produced a significant lowering of cholesterol in a hypertension model and it inhibits the activity of the hormones sensitive lipases in adipose tissue and suppresses the release of triglycerides when it is administered orally at the dose of 400, 600 and 800 mg kg body weight once a day to the groups for 30 days 24.
Antiobesity Study: G. Sylvestre advances weight reduction perhaps through its capacity to diminish desires for desserts and control glucose levels. It has been accounted for that the gurmarin peptide hinders the capacity to taste sweet or unpleasant flavors and consequently diminishes sweet desires. An institutionalized G. sylvestre extricate in mix with niacin-bound chromium and hydroxycitric corrosive has been assessed for antiobesity movement by observing changes in body weight, weight record (BMI), hunger, lipid profiles, seruleptin and discharge of urinary fat metabolites.
This examination demonstrated that the mix of Gymnema sylvestre separate and hydroxycitric corrosive, niacin bound chromium can fill in as a compelling and safe weight reduction equation that can encourage a lessening in abundance body weight and BMI while advancing sound blood lipid levels 25. Leaves extract of Gymnema sylvestre is rich in gymnemic acids that help in the inhibition of fat and oil hydrolyzates absorption from the digestive tract and thus show a potent antiobesity effect 26.
Antimicrobial Activity: The ethanolic concentrate of G. sylvestre leaves demonstrated great antimicrobial activity against Bacillus pumilis, B. subtilis, Pseudomonas aeruginosa and Staphylo-coccus aureus and no action was found against Proteus vulgaris and Escherichia coli 27. The fluid and methanolic concentrate of G. sylvestre leaves likewise demonstrated direct movement against the three pathogenic Salmonella species (Salmonella typhi, S. typhimurium and S. paratyphi). Out of the two concentrates utilized, fluid concentrate demonstrated higher movement against the Salmonella species 28. Ethanolic, Chloroform an Ethyl acetic acid derivation concentrates of the ethereal parts of G. sylvestre likewise answered to have antibacterial impacts against P. vulgaris, E. coli, P. aeroginosa, Klebsella pneumoniae and S. aureus 29. Fruit and root extracts of G. sylvestre showed zones of inhibition at the concentration of 100 mg/ml. G. sylvestre fruit extract shows inhibition zones for different bacterial species like Staphylococcus aureus (8.7 mm), Bacillus subtilis (11.66 mm), Escherichia coli (13 mm), Klebsiella aerogenes (12 mm) as well as fungal species like Aspergillus niger (10.75 mm). The root extract of G. sylvestre exhibits zone of inhibition for Staphylococcus aureus (11.5 mm), Bacillus subtilis (10.66 mm), Escherichia coli (15.5 mm), Klebsiella aerogenes (mm) as well as fungal species like Aspergillus niger (11.33 mm) 30.
Anti-Inflammatory Activity: The aqueous extract of G. sylvestre leaves was researched for assessment of anti-inflammatory action in rats at measurements 200, 300 and 500 mg/kg in carrageen in prompted paw oedema and cotton pellet strategy. The fluid concentrate at 300, 26 mg/kg diminished the paw oedema volume by 48.5% inside 4 h after organization, while the standard medication phenylbutazone diminished the edema volume by 57.6% when contrasted and the paw oedema volume of control. The watery concentrate at the dosage of 200 mg/kg and 300 mg/kg delivered critical diminishment in granuloma weight, when contrasted with control gathering 31.
Free Radical Scavenging Activity: In vitro, the inhibitory impacts of DPPH radicals and LDL oxidation were found with fluid concentrate of G. sylvestre. G. sylvestre require 32.1 μl, for searching half of the DPPH radicals 32.
Effect on Taste: Gymnema or more specifically the gurmarin peptide, has been reported to block the ability to taste sweet or bitter flavors. Interference with Na+/K+ ATPase activity of taste receptor has been proposed as a possible mechanism of action. The transient effect on taste is only present when the fresh or dry leaves are chewed 33.
Antiviral Activity: Gymnemic acids A, B, C and D were tried for antiviral action against flu infection. Gymnemic corrosive A (75 mg/kg/day, IP) demonstrated the best action, direct hindrance was acquired with gymnemic corrosive B and none with gymnemic acids C and D.
Antibacterial Activity: Antibacterial exercises of hydro-methanolic separate from leaves of Gymnema sylvestre was researched utilizing the disk dispersion strategy given by Kerby-Bauer plate diffusion susceptibility test. The zone of restraint (in mm) Gymnema sylvestre separate showed solid antibacterial exercises for both strain [gram (+) and gram (-) bacteria] half methanolic concentrate of leaves of Gymnema sylvestre at the diverse focus i.e. 25%, half, 75%, 100% displayed antibacterial against and E. coli, Klabsella, Staphylococcus and Psuedomonas 34 .
Antioxidant Activity: Antioxidant activity of Gymnema sylvestre extricates (10 - 100 μg/ml) were resolved concurring de-oxyribose strategy (Fenton response) of halliwell and aruoma against ascorbic corrosive as standard. In vitro cell reinforcement exercises of Gymnema sylvestre extricate demonstrated noteworthy inhibitory focus when contrasted with ascorbic corrosive 31. The dynamic compound C-4 pearl dimethyledoleanes of GS remove additionally forces cell reinforcement action. The IC50 esteems for DPPH searching, superoxide radical rummaging, restraint of in vitro lipid peroxidation, and protein carbonyl arrangement were 238, 140, 99 and 28 μg/mL, individually 35. The cancer prevention agent movement appeared by the 55% v/v alcoholic GS concentrate might be because of the nearness of flavonoids, phenols, tannins and triterpenoids, which were all identified in preparatory phytochemical screening 36.
In vivo contemplates have demonstrated that pre-treatment with GS separates altogether upgraded the radiation (8 Gy)- prompted increase of lipid peroxidation and exhaustion of glutathione and protein in mouse mind. Some multi-home grown Ayurvedic plans containing concentrates of GS, for example, hyponid and dihar, have indicated cell reinforcement movement by expanding the levels of superoxide dismutase, glutathione and catalase in rats 37, 38. According to Kaskoos (2015) 39, the antioxidant activities of G. sylvestre (leaves) and their composite extract were determined by using a methanolic solution of DPPH. The result of antioxidant activity of G. sylvestre (leaves) showed concentration dependent response and it varied from 3.92 to 72.22% for the concentration of 7.81 to 1000 μg/ml, respectively. The IC50 values of G. sylvestre extract was found to be 140 μg/ml.
Hepatoprotective Activity: Shafeyet (2013) 19 done an experiment and agreed with Shanmuga-sundaram (1983) 40, where it was reported that, by administering dried leaf powder of G. sylvestre it helps to lower the glucose level and thus it help to maintain balanced Gluconeogenic enzymes (ALT and AST) and expanded glycogen levels in liver, kidney and muscle.
Chemopreventive Activity: Nowadays, the chemo preventive action of Gymnema sylvestre plant was effectively recognized. Gymnema sylvestre leaves separate against 7, 12 - dimethylbenz (an) anthracene (DMBA) incited papillomagenesis in Swiss pale skinned person mice was considered. The methanolic concentrate of Gymnema sylvestre was investigated for chemopreventive action. Chemopreventive action was assessed by two phase convention comprising of start with a solitary topical utilization of a cancer causing agent (7, 12 - dimethylbenz (an) anthracene (DMBA) trailed by a promoter (croton oil) two times in seven days were utilized. A noteworthy lessening in tumor rate, tumor load and total number of papillomas was seen, alongside a huge increment in normal idle period in mice treated tropically with Gymnema sylvestre separate when contrasted with the control assemble treated with DMBA and croton oil 34. Aside from every one of these exercises, The plant is accounted for to be severe, astringent, harsh, thermogenic, calming, anodyne, stomach related, liver tonic emetic, diuretic, stomachic, stimulant, anthelmenthics, purgative, cardiotonic, expectorant, antipyretic and uterine tonic 41. It is helpful in dyspepsia, stoppage, jaundice, hemorrhoids, renal and vesical calculi, cardiopathy, asthma, bronchitis, amenorrhoea, Conjunctivitis and leucoderma 42.
Toxicity: The LD50 of ethanol and water extract of Gymnema administered intraperitoneally in mice was found to be 375 mg/kg 43.
CONCLUSION: The present and previous all the studies have demonstrated that Gymnema sylvestre has a wide range of therapeutic effects. Presently, plant originated natural compounds got a significant endurance for the purpose of safe medicinal use by being tested their effectiveness and efficacy. Because of diabetes being turned into a basic illness throughout the world, people have started using herbs as a conventional practice for the treatment of this disease. G. sylvestre, has achieved a vital place among such antidiabetic restorative plants which have hypoglycemic and hypolipidemic action in long haul treatment. G. sylvestre has not only anti-diabetic property it can also be useful for weight loss, metabolic syndrome, cough, snake bite antidote, antihelminthic, antipyretic, astringent, an alexipharmic, cardiotonc, digestive, diuretic, hemorrhoids, jaundice and lucoderma. Though some other investigations, such as physiochemical characterization, biological evaluation, toxicity studies, and investigation of molecular mechanism of action of isolated compounds are going on, clinical trials on G. sylvestre might help to draw their unquestionable pharmacological effect on human body.
ACKNOWLEDGEMENT: Great thanks to the Faculty of Biological Sciences, Jahangirnagar University, for providing the required facilities for the completion of this article.
CONFLICT OF INTEREST: The author declares that there is no conflict of interest regarding this study.
- Singh R: Medicinal Plants. A Review. Journal of Plant Sciences 2015; 3(1): 50-55.
- Rafieian-Kopaei M: Medicinal plants and the human needs. Journal of Herb Med Pharmacology 2012; 1(1): 1-2.
- Satdive K, Abhilash P and Devanand PF. Antimicrobial activity of Gymnema sylvestre leaf extract. Fitoterapia, 2003; 74(7-8): 699-701.
- Wani M, Sarvar FA, Agrawal J, Deshpande J, Mathew S and Khetmalas M: Qualitative phytochemical analysis and antimicrobial activity studies of Gymnema sylvestre Br. Acta Biologica Indica 2012; 1(1): 121-124.
- Keshavamurthy KR and YS: Flora of Coorg- Karnataka. Banglore: Vimsat publishers 1990.
- Ansari MS, Alam P and Ahmed SM: Pharmacognostic and phytochemical analysis of Gymnema sylvestre (Br) leaves. Journal of Herbal medicine and Toxicology 2009; 3(1): 73-80.
- Potawale ESV: Green synthesis of copper nanoparticle using Gymnema sylvestre by different solvent extract. Pharmacology online, 2008; 2: 144-157.
- Khramov VA and SA: Chemical composition of dry extracts of Gymnema sylvestre Pharmaceutical Chemistry Journal 2008; 42(1): 29-31.
- Kuzuko Y and KA: Structure studies of new antisweet constituents from Gymnema sylvestre. Tetrahedron lett, 1989; 30(9): 1103-1106.
- Liu X and YW: Two new flavonol glycosides from Gymnema sylvestre and Euphorbia ebracteolata. Carbohydrate Research 2004; 339(4): 891-895.
- Fabio GD, Romanucci V, Zarrelli M, Giordano M and Zarrelli A: C-4 Gem-Dimethylated Oleanes of Gymnema sylvestre Molecules 2013; 18: 14892-14919.
- Shanmugasundaram ERB, Rajeswari G, Bhaskaran K, Kumar BRR, Shanmugasundaram KR and Ahmath BK: Use of Gymnema sylvestre leaf extract in the control of blood glucose in insulin dependent diabetes mellitus. J. Ethnopharmacology 1990a; 30(3): 281-294.
- Shanmugasundaram ERB, Gopinath KL, Shanmuga-sundaram KR and Rajendran VM: Possible regeneration of islets of langerhans in streptozotocin-diabetic rats given Gymnema sylvestre leaf extracts. J. Ethnopharmacology 1990b; 30(3): 265-279.
- Chatopadhyay RR, Medda C, Das S and Basu TK: Hypoglycemic and antihyperglycemic effect of Gymnema sylvestre leaf extract in rats. Fitoterapia 1993; 64: 450-454.
- Persaud SJ, Al-Majed H, Raman A and Jones PM: Gymnema sylvestre stimulates insulin release in vitro by increased membrane permeability. J. Endocrinology, 1999; 163: 207-212.
- Gholap S and Kar A: Effects of Inularacemosaroot and Gymnema sylyestre leaf extracts in the regulation of corticosteroid induced diabetes mellitus: involvement of thyroid hormones. Pharmazie 2003; 58: 413-415.
- Gholap S and Kar A: Hypoglycaemic effects of some plant extracts are possibly mediated through inhibition in corticosteroid concentration. Pharmazie 2004; 59: 876-78.
- Mutalik S, Chetana M, Sulochana B, Devi PU and Udupa N: Effect of Dianex, an herbal formulation on experimentally induced diabetes mellitus. Phytotherapy Research 2005; 19(5): 409- 415.
- El Shafeyet AAM, El-Ezabi MM, Seliem MME, Ouda HHM and Ibrahim DS: Effect of Gymnema sylvestre Br. leaves extract on certain physiological parameters of diabetic rats, Journal of King Suad University-Science 2013; 25: 135-141.
- Sathiavelu A, Sangeetha S, Archit R and Mythili S: In vitro anti-diabetic activity of aqueous extract of the medicinal plants Nigella sativa, Eugenia jambolana, Andrographis paniculata and Gymnema sylvestre. International Journal of Drug Development and Research 2013; 5(2): 323-328.
- Kumar HV, Nayak NIM, Huilgol SV, Yendigeri SM and Narendar K: Antidiabetic and hypolipidemic activity of Gymnema sylvestre in dextramethasone induced insulin resistance in albino rats. International journal of medical research and health sciences 2015; 4(3); 639-645.
- Kumar P, Rani S, Arunjyothi B, Chakrapani P and Rojarani A: Evaluation of Antidiabetic activity of Gymnema sylvestre and Andrographis paniculata in streptozotocin Induced Diabetic Rats. International Journal of Pharm and Phy Res 2017; 9(1): 22-25.
- Bishayee A and Chatterjee M: Hypolipidaemic and antiatherosclerotic effect of oral Gymnema sylvestre Br. leaf extract in albino rats fed on a high fat diet. Phytotherapy Res. 1994; 8(2): 118-120.
- Mall GK, Mishra PK and Prakash V: Antidiabetic and Hypolipidemic Activity of Gymnema sylvestre in Alloxan Induced Diabetic Rats. Global Journal of Biotechnology and Biochemistry 2009; 4(1): 37-42.
- Ninomiya Y and Imoto T: Gurmarin inhibition of sweet taste responses in mice. American Journal of Physiology 1995; 268 (4): 1019-25.
- Singh DK, Sachan A, Kumar N, Lakhani P, Tutu S, Shankar P, Nath R, Kumar A and Dixit RK: Evaluation of antiobesity effect of Gymnema sylvestre and Acorus calamus on diet induced model of obesity in rats. International journal of pharmaceutical science and research 2017; 8(10): 4341-47.
- Satdive K, Abhilash P and Devanand PF: Antimicrobial activity of Gymnema sylvestre leaf extract. Fitoterapia, 2003; 74(7-8): 699-701.
- Pasha C, Sayeed S, Ali S and Khan Z: Antisalmonella Activity of Selected Medicinal Plants. Turk J Biol. 2009; 33: 59-64.
- Paul JP and Jayapriya K: Screening of antibacterial effects of Gymnema sylvestre (L.) R.Br. - A medicinal plant. Pharmacologyonline 2009; 3: 832-836.
- Pingale SS, Rupanar SV and Chaskar MG: Evaluation of antimicrobial activity of Gymnema sylvestre. International research journal of pharmacy 2017; 8(3): 2230-8407.
- Malik JK, Manvi FV, Alagawadi KR and Noolvi M: Evaluation of anti-inflammatory activity of Gymnema sylvestre leaves extract in rats. Int J Green Pharm 2008; 2(2): 114-15.
- Ohmori R, Iwamoto T, Tago M, Takeo T, Unno T and Itakura H: Antioxidant activity of various teas against free radicals and LDL oxidation. Lipids 2005; 40(8): 849-53.
- Pierce A: Gymnema Monograph: Practical guide to natural medicine, Stonesong Press Book, New York 1999; 324-26.
- Agrawal RC, Soni S, Jain N, Rajpoot J and Maheshwari SK: Chemopreventive effect of Gymnema sylvestre in Swiss albino mice, International Journal of Scientific and Research Publications 2016; 6(1): 78-83.
- Sharma K, Singh U, Vats S, Priyadarsini K, Bhatia A and Kamal R: Evaluation of evidenced-based radioprotective efficacy of Gymnema sylvestre leaves in mice brain. J. Environ. Pathol. Toxicol. Oncol. 2009; 28: 311-323.
- Yeh GY, Eisenberg DM, Kaptchuk TJ and Phillips RS: Systematic review of herbs and dietary supplements for glycemic control in diabetes. DC 2003; 2: 1277-1294.
- Babu PS and Stanely MPP: Antihyperglycaemic and antioxidant effect of hyponid, an Ayurvedic herbomineral formulation in streptozotocin-induced diabetic rats. J. Pharm. Pharmacol. 2004; 56: 1435-1442.
- Patel SS, Shah RS and Goyal RK: Antihyperglycemic, antihyperlipidemic and antioxidant effects of dihar, a polyherbal ayurvedic formulation in streptozotocin induced diabetic rats. Indian J Exp Biol 2009; 47: 564-570.
- Kaskoos RA, Hagop AB, Faraj AM and Ahamad J: Comparative antioxidant activity of Gymnema sylvestre, Enicostemma littoral, Momordica charantia and their composite extract. Journal of Pharmacognosy and Phytochemistry 2015; 4(1): 95-98.
- Shanmugasundaram KR, Panneerselvam C, Samudram P and Shanmugasundaram ERB: Enzyme changes and glucose utilization in diabetic rabbits: the effect of Gymnema sylvestreBr. J Ethn 1983; 7(2): 205-234.
- MUM: Monographs of Unani Medicine, Vol-1. Bait al-Hikmah, Hamdard Foundation. Pakistan, Islamabad, Pakistan 2003; 271-272.
- Nadkarni KM: Indian Materia Medica; Popular prakashan, Bombay 1993; 1: 596-599.
- Bhakuni DS, Dhar ML, Dhar MM and Dhawan BN: Screening of Indian plants for biological activity: Part III. Ind. J. Exp. Biol. 1971; 9: 91-102.
How to cite this article:
Dash PR, Sikta SA, Mahbub J, Shermin F and Islam F: Phytochemistry and pharmacological properties of Gymnema sylvestre (asclepiad-daceae): A review. Int J Pharmacognosy 2018; 5(4): 198-04:.doi link: http://dx.doi. org/10.13040/IJPSR.0975-8232.IJP.5(4).198-04.
This Journal licensed under a Creative Commons Attribution-Non-commercial-Share Alike 3.0 Unported License.
P. R. Dash * , S. A. Sikta, Jerin Mahbub, F. Shermin and F. Islam
Department of Pharmacy, Jahangirnagar University, Savar, Dhaka, Bangladesh.
04 December, 2017
09 January, 2018
13 February, 2018
01 April, 2018