PHYTOCHEMICAL ANALYSIS, ANTIOXIDANT ACTIVITY AND GROWTH INHIBITORY EFFECTS OF EXTRACTS FROM ANNONA SENEGALENSIS, WALTHLERIA INDICA AND ANTHOCLEISTA VOGELIIAbstract
Antioxidant potential, phytochemical and growth inhibitory characteristics of Anthocleista vogelii stem bark (AVSB) and root (AVRT), Annona senegalensis stem bark (ANSB) and Waltheria indica leaf (WILV) aqueous extracts were evaluated. Phytochemical analysis showed the presence of flavonoids, tannins, saponins, sterols, alkaloids, and terpenes. Fourier Transform Infra-Red (FT-IR) analyses indicated the presence of O-H, C-H, C=O, C=C, N-H and C-O bonds. AVSB, AVRT, ANSB, and WILV significantly (P<0.001) and dose-dependently (1-32 mg/mL) inhibited Sorghum bicolor seed radicle growth throughout 24-72 h compared with the control seeds. This result indicated the propensity of Anthocleista vogelii (stem bark and root), Annona senegalensis (stem bark) and Waltheria indica (leaf) extracts to inhibit the proliferation of fast-growing cells. The presence of the phytochemicals and the inhibitory activity of the extracts provided a preliminary indication of their cytotoxicity and potential for the management of cancer.
I. L. Fayum, C. I. Buba, J. Atogwe, D. C. Okeoma and S. E. Okhale *
Department of Medicinal Plant Research and Traditional Medicine, National Institute for Pharmaceutical Research and Development, Idu Industrial Area, P.M.B. 21 Garki, Abuja, Nigeria.
11 September 2018
07 October 2018
20 October 2018
01 November 2018