IN-SITU RAFT FORMING SYSTEM: A REVIEWAbstract
Oral delivery of drug is the most preferable drug delivery due to the ease of administration, patient compliance and flexibility in the formulations. In recent era various technologies have been made in research and development of controlled release oral drug delivery system to overcome various physiological difficulties such as variation in gastric retention and emptying time. Conventional oral dosage forms pose low bioavailability problems due to their rapid gastric transition from stomach, especially in case of drugs which are less soluble at alkaline pH of intestine and locally acting drugs in stomach get rapidly emptied. So, frequency of dose administration in such cases is increased. Gastro retentive drug delivery system is facing many challenges which can be overcome by upcoming newly emerging approach i.e. raft forming system. The present study provides valuable information and highlights advances in this raft forming system. Different types of smart polymers used for their formulation have also been summarized. The review focuses on the mechanism, formulation, development and system optimization aspects of the raft forming system and also highlight parameters which may lead to response variations in altered physiological conditions are discussed as well.