EVALUATION OF METHANOLIC EXTRACT OF CLITORIA TERNATEA HEPATO-PROTECTIVE AND NEPHROPROTECTIVE ACTIVITY IN RATSAbstract
Objective: The aim of the study was to investigate the nephroprotective and hepatoprotective activity of methanolic extract of Clitoria ternatea in cisplatin and CCl4 induced in rats. Methods: Methanolic extract of aerial part of Clitoria ternatea plant was studied for its nephroprotective and hepatoprotective activity in animal experimental models. Nephrotoxicity was induced by cystone 16 mg/kg b.w. The standard drug was taken silymarin. The test drug was given methanolic extract Clitoria ternatea 500 mg/kg, 1000 mg/kg. Hepatoxicity was induced by CCl4. The standard drug was taken cisplatin 100 mg/kg. Test drugs were given extract of Clitoria ternatea 500 mg/kg and 1000 mg/kg as per b.w. Results: In hepatoprotective activity positive control group was provided with CCl4 and increased SGPT, SGOT, ALP level compare to negative control group whereas test 2 group was provided with methanolic extract of Clitoria ternatea 1000 mg/kg decreased SGPT, SGOT, ALP level compare to standard group. In nephroprotective activity positive control group was provided with CCl4 increased urea and creatinine level whereas test 2 group are provided with methanolic extract of Clitoria ternatea 1000 mg/kg decreased urea and creatinine level. Conclusion: On evaluating biochemical parameters it was found that methanolic extract of Clitoria ternatea 1000 mg/kg showed hepatoprotective and nephroprotective activity in rats.
S. Chandra *, A. Das, T. Roy, P. Bose, L. Mukherjee and J. Samanta
Department of Pharmacology, Jakir Hossain Institute of Pharmacy, Raghunathganj, Murshidabad, West Bengal, India.
25 August 2019
23 September 2019
27 September 2019
30 September 2019