EVALUATION OF ANTIHYPERTENSIVE ACTIVITY OF NATURAL MIXTURE AND INVESTIGATION OF HERB-HERB INTERACTIONAbstract
Hypertension is a common clinical problem encountered in day-to-day practice. Although several synthetic pharmaceutical drugs already exist for the treatment of hypertension, these drugs can develop many complicated side effects. On the other hand in our Arabian countries, patient compliance forces the population to frequently recourse to traditional medicine which mainly uses plants. Because of most of the medicinal agents including herbs were reported to have potentially unexpected effects including toxicity and interactions, this study focused on the investigation of antihypertensive activity of four plants mixture along with studying their interaction. In this study ethanolic extract of a mixture composed of four plants Hyphaene thebaica, Olea europaea, Origanum majorana, and Hibiscus sabdariffa was investigated for its antihypertensive activity and interaction between it’s including herbs. 50 g of each plant powder was mixed homogeneously and macerated in 70% ethanol for about 7 days. The effect of this extract was investigated at a dose level of 25 mg/kg. Blood pressure was measured by a non-invasive blood pressure recorder apparatus before and after treatment. The results of this comprehensive study revealed that aqueous extract of this natural mixture showed a significant decrease in SBP as compared to fludrocortisone-induced hypertensive control mice. It was revealed that aqueous extract showed a hypotensive effect nearly equal to slandered control (captopril). According to the histopathology study, aq. The extract showed a protective effect against alterations and pathological changes that were induced by hypertension in the kidney.
S. Shabana *, M. Fouad, A. Zaki, R. El-Haggar, M. J. Sadiq, N. M. S. Osman and I. A. Sindi
Department of Pharmacognosy, Faculty of Pharmacy, MISR University for Science and Technology (MUST), Cairo, Egypt.
20 April 2018
09 June 2018
13 June 2018
01 August 2018