EVALUATION OF ANTI-DIABETIC ACTIVITY ON n-BUTANOL FRACTION OF LEAF METHANOLIC EXTRACT OF CURCULIGO ORCHIOIDES (AMARYLLIDACAE) IN STREPTOZOTOCIN INDUCED DIABETIC RATSAbstract
The aim of the present study to evaluate the anti-diabetic activity of methanolic extract n-butanol fraction of Curculigo orchioides (Amaryllidaceae) against in streptozotocin-induced diabetic rats. Fractions were administrated orally at 200 mg/kg and 100 mg/kg for 3weeks. The effects were compared with an oral dose of 10 mg/kg of glibenclamide. Blood glucose levels are a determination by GOD-POD kit method. In the results, our study indicates that Curculigo orchioides n-butanol fraction of leaf methanolic extract exhibited significant antihyperglycemic activities in streptozotocin-induced hyperglycemic rats without significant change in body weight. And shows the values are given in average body weight (g) ± SEM for groups of six animals each. A) Normal saline. B) Normal saline + streptozotocin. Significance vs. Control group *P < 0.01. **P < 0.005, ***P < 0.0001.
Department of Pharmacognosy, Sahasra Institute of Pharmaceutical Sciences, Warangal, Telangana, India.
11 November 2017
19 January 2018
22 February 2018
01 March 2018