ANTIDIABETIC EFFECT OF ETHANOLIC EXTRACT OF MURRAYA KOENIGII (LINN.) STEM BARK IN ALLOXAN INDUCED DIABETIC RATSAbstract
Introduction: The objective of the present work was to study the antidiabetic effect of ethanolic extract of Murraya koenigii stem bark (EEMK) in alloxan-induced diabetic rats. Materials and Methods: Male Wistar albino rats weighing between 150-250 g were used for this study. The rats were divided into five groups (n=6). Group, I served as the diabetic control, group II served as diabetic control, groups III, IV served as test groups, and group V served as a standard group. The diabetes was induced by a single dose of alloxan (140 mg/kg, i.p.) in all the groups except normal control group. Then the rats of respective groups were treated with normal saline, EEMK (125 mg/kg and 250 mg/kg) and metformin (50 mg/kg) for 11 days. Blood glucose estimation was performed on 0, 1, and 11 days. At the end of this study period, animals were sacrificed for studying biochemical parameters. Results: Alloxan-induced diabetic rats showed marked hyperglycemia at the end of the study period. Body weight and liver glycogen levels were reduced in diabetic rats. The 11-day treatment with EEMK (125 mg/kg and 250 mg/kg) significantly ameliorated the alterations in fasting blood glucose, serum triglycerides, serum cholesterol, liver glycogen, and body weight in diabetic rats. Moreover, the oral glucose tolerance test revealed that the extract was found to increase glucose tolerance. Conclusion: Thus, the present study suggested the potential of EEMK in diabetes mellitus.
M. C. Upadhye *, U. A. Deokate and R. R. Pujari
Department of Pharmacognosy, Modern College of Pharmacy (Ladies), Borhadewadi, Moshi, Pune, Maharashtra, India.
06 May 2019
19 June 2019
23 June 2019
30 June 2019