EVALUATION OF THE IMMUNOMODULATORY EFFECT OF PIPLARTINE AND ITS DERIVATIVE ON PERITONEAL MACROPHAGES OF SWISS MICE INFECTED WITH LEISHMANIA AMAZONENSIS
Piplartine is an amide obtained from Piper tuberculatum, which is promising in antiparasitic tests. Therefore, it has been used as the basis for the synthesis of new molecules. This study was designed to analyze the immunomodulatory effect of piplartine (A) and its derivative (B), in-vitro, on macrophages infected with Leihmania amazonensis, as well as the production of hydrogen peroxide (H2O2), n...
PHYTOCHEMICAL SCREENING OF AQUEOUS AND ETHANOL EXTRACTS OF SOME MEDICINAL PLANTS AND IN -VITRO STUDY OF INHIBITION OF α- AMYLASE
In the present study we screened four medicinal plants for the α-amylase inhibitory activity of each extracts phytochemicals, and it was determined based on the colorimetric assay using acarbose as a reference compound. The aqueous and ethanol extracts of the medicinal plants viz. Enicostemma littorale, Achyranthes aspera, Abutilon indicium, and Tridax procumbens were shown moderate α-amylase in...
Plants have been used for centuries as a remedy for human diseases because they contain phytochemical components of therapeutic values. The whole plant of the Trigonella foenum, Zea mays and Oryza sativa were selected for in this study to find out the phytochemicals and antioxidant property. Phytochemicals were extracted using various solvents such as Hexane, Ethyl acetate, and ethanol. Screening ...
Many herbal remedies have been employed in various medical systems for the treatment and management of different diseases. The plant Lagenaria siceraria, a plant belonging to the family Cucurbitaceae, has been used in the different system of traditional medication for the treatment of diseases and ailments of human beings. The n-hexane extract of Lagenaria siceraria was screened for antimicrobial ...
Rice bran is the cuticle existing between the rice and husk of the paddy and consists of embryo and endosperm of the seeds of Oryza sativa, family Gramineae. It is obtained as a by product in rice mill during polishing of rice obtained after dehusking of paddy. Rice bran contains about 15% of fixed oil and is obtained by the solvent extraction method. It contains oleic acid, linolenic acid as unsa...
ANTIDIABETIC ACTIVITY ETHANOLIC LEAVES EXTRACT OF BAUHINIA GALPINII LINN. ALLOXAN INDUCED DIABETIC IN RATS
Aim of the study: This study aimed to investigate the antidiabetic activity of ethanolic leaves extracts of Bauhinia galpinii Linn. alloxan, induced diabetic in rats. Materials & methods: The adult male albino rats of weight 180-240 gm were selected for the study. The Dose of 100 mg/kg, 250 mg/kg and 500 mg/kg of ethanol extract was selected for the test. All the doses were given orally after ...
A study was conducted to assess root, leaves and flowers extracts of Cichorium intybus for their antimicrobial activities (against four bacterial and fungal strains), antioxidants activities (DPPH, ABTS H2O2 and reducing power assays) and cytotoxicities assays. The results indicate remarkable inhibition of plant extracts for the growth of all bacterial and fungal strains as well as appropriate MIC...
NATURAL REMEDIES TARGET DIFFERENT THERAPEUTIC PATHWAYS IN ORAL MUCOSITIS INDUCED BY CANCER CHEMO OR RADIOTHERAPY
Oral mucositis (OM) is an inflammatory condition affecting oral mucosa. The etiology of this type of inflammation is associated with exposure to radiotherapy or chemotherapeutic drugs. Herbal drugs have been used to induce healing of different types of gastrointestinal ulcers. The role of medicinal plant in cancer therapy-induced oral mucositis has been investigated extensively. Preclinical studie...
Thevetia Peruviana (or Cascabela thevetia) belongs to the family Apocynaceae and commonly called as Yellow Oleander. The leaves of this significant medicinal plant were subjected to antibacterial investigation and HPLC analysis. Hexane, acetone, and methanol were used as organic solvents. Four different concentrations (200 mg/ml, 100 mg/ml, 50 mg/ml and 25 mg/ml) of each extract i.e. hexane, aceto...
The present investigation was designed to prepare immediate release tablets of gliclazide with the ultimate aim of reducing the time needed to obtain the peak plasma concentration. Gliclazide immediate release tablets were prepared by using superdisintegrants namely- sodium starch glycolate and croscar-mellose sodium. The prepared tablets were evaluated for weight variation, hardness, friability, ...