EVALUATION OF ANTIHYPERTENSIVE ACTIVITY OF NATURAL MIXTURE AND INVESTIGATION OF HERB-HERB INTERACTION
Hypertension is a common clinical problem encountered in day-to-day practice. Although several synthetic pharmaceutical drugs already exist for the treatment of hypertension, these drugs can develop many complicated side effects. On the other hand in our Arabian countries, patient compliance forces the population to frequently recourse to traditional medicine which mainly uses plants. Because of m...
Aim of this study was to generate a model of DHNA using protein sequence and homology modeling and then dock the modeled protein with an inhibitor. Molecular docking is a frequently used method in structure-based rational drug design. It is used for evaluating the complex formation of small ligands with large biomolecules, predicting the strength of the bonding forces and finding the best geometri...
Diabetes mellitus is a metabolic disorder in which blood glucose level decrease. Due to this disease, various complications are arises including retinopathy, nephropathy, cardiovascular disease, and neuropathy. Diabetes mellitus is a chronic condition includes Type 1 DM, Type 2 DM and gestatational diabetes, which occurs in pregnancy. For the management of DM various system of medicine is used, fr...
HEPATOPROTECTIVE ACTIVITY OF UVARIA NARUM IN PARACETAMOL-INDUCED HEPATIC DAMAGE IN RATS: A BIOCHEMICAL AND HISTOPATHOLOGICAL EVALUATION
Uvaria narum Wall (Annonaceae) is described as a hepatoprotective in Ayurveda, the Indian system of medicine. However, there are no scientific reports in the modern literature regarding its usefulness as a hepatoprotective agent. The present study was carried out to evaluate the hepatoprotective activity of alcoholic (UNAL) and aqueous (UNAQ) extracts of leaves of Uvaria narum Wall in paracetamol-...
The present study was investigated to determine the possible phytochemical components from the solvents such as hexane, ethyl acetate and ethanolic extract of Justicia tranquebariensis. Among the phytochemical screening of these extracts, ethyl acetate extract showed that the whole plant was rich in carbohydrate, tannin, flavonoids, quinones, cardiac glycosides, phenols, steroids, and coumarins. F...
Sonchus arvensis, a perennial sowthistle, is a common but underutilized species of Kathmandu, Nepal. Several uses like sedative, antioxidant and kidney stone eradicating properties have been identified till date, but a study on other pharmacological activities is not yet explored. Therefore, the plant was collected from Kathmandu; aerial parts of the plant were dried, crushed, and extracted using ...
The synthetic indicators are used in acid-base titration for determination of endpoint. A part of its application, the synthetic indicators has several limitations such as toxic, costly, corrosive, etc. Thus, herbal indicators are the choice of today for acid-base titrations. The natural indicator is easy to extract as well as easily available. Promising results were obtained when it was compared ...
Teucrium polium L. is a member of the Lamiaceae family and is represented in the Flora of Syria by two variety: Teucrium polium var. angustifolium and Teucrium polium var. mollissimum. Teucrium polium is a wild-growing flowering plant, found abundantly in Syria, and it is used traditional medicine for it's diuretic, antipyretic, antispasmodic, tonic, anti-inflammatory, antihypertensive, anorexic, ...
Dregea volubilis (L.f.) Benth. Ex Hook. f. is a large twinning shrub belonging to the family Asclepiadaceae. The leaf is amphistomatic with tetracytic, anomocytic, paracytic stomata. The sides of the leaf in the surface are straight to curved, surface striated on either side. The mesophyll is interspersed with sphaerocrystalliferous idioblasts. Midvein consists of a single arcuate vascular bundle,...
PHYTOCHEMICAL STUDY AND EVALUATION OF WOUND HEALING POTENTIAL OF CRUDE LEAVE EXTRACTS OF OROXYLUM INDICUM (L.) VENT IN WISTAR RATS
The present study was carried out to evaluate the wound healing potential of different extracts of Oroxylum indicum leave in two different types of wound models in albino rats viz., incision and excision, and compare the effects with povidone iodine ointment which is used as standard drug. Among all the extract, the ethanolic extract at a dose of (250 mg/kg) possesses a significant increase in wou...