2-Amino-1-aryl-1,4,5,6,7,8-hexahydro-4-phenylquinoline-3-carbonitrile derivatives were synthesized by the reaction of cyclohexanone (1) with 2-benzylidinemalononitrile (2) and the appropriate of aniline derivatives. The reactivity of some of these newly synthesized derivatives toward carbon disulfide and further toward hydrazonoyl halides were also studied. In addition, the antimicrobial activity ...
The leaf of Verbena officinalis was collected, air dried under shed, powdered, soaked in and extracted with 80% methanol. The crude extract was tested for its in vitro antibacterial activity against S. aureus and E.coli using agar disc diffusion method. Antibacterial assay was made using extract concentrations of 250mg/ml, 500mg/ml, and 1000mg/ml. The extract showed a concentration dependent zone ...
HEPATOPROTECTIVE ACTIVITY OF ETHANOLIC EXTRACT FROM THE STEM BARK OF SYNEDRELLA NODIFLORA ON CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY IN SWISS ALBINO RATS
The ethanol extracts of steam bark of Synedrella nodiflora belonging to the family of Asteraceae was studied for hepatoprotective activity against Swiss Albino Rats with liver damage induced by carbon tetrachloride (CCL4). It was found that the ethanol extract of Synedrella nodifloraat a dose of 250mg/kg body weight exhibited significant protective effect by lowering the serum level of alanine ami...
Kidney stone is one of the most prevalent disease worldwide calcium oxalate has been shown to be the main components of the majority of stones formed in the urinary system of the patients with urolithiais.The main objective is to study the inhibition effect of coleus Aromaticu benth. On the Calcium Oxalate crystal. The antilithiatic activity of Coleus Aromaticus was investigated on nucleation grow...
Cancer is a disease of deregulated cellular behavior. Acquisition of oncogenic attributes, loss of tumor suppressive functions, evasion of physiological tissue architecture and interactions with the cellular microenvironment enable malignant cells to escape the mechanisms of normal cellular homeostasis in an organism. Cancer cells are therefore able to sustain unlimited proliferation, to thrive un...
In this review, the current knowledge on the phytochemistry and pharmacology of Piper betle (betel), Piper sarmentosum (wild pepper) and Piper caninum (wild betel) is updated with some description of their botany and uses. Leaves of P. betle contain polyphenols, alkaloids and essential oils, and display broad-spectrum antibacterial activity, substantial quorum sensing inhibition and tyrosinase enh...
PHYTOCHEMICAL SCREENING AND EVALUATION OF VARIOUS EXTRACTS OF LAGENERIA SICERARIA FOR ANTIOXIDANT ACTIVITY
Lageneria siceraria commonly known as Bottle gourd Syn. Doodhi , Syn.Lauki (Hindi )Kadoo ( Marathi) which is official in Ayurvedic Pharmacopoeia Preliminary phytochemical screening of the crude extracts revealed the presence of carbohydrates , Proteins etc and secondary metabolites like saponins , glycosides , alkaloids etc. in all the extracts but tannins were found absent i...
The normal steady state of the human body’s organ and tissue function is termed as homeostasis. One significant factor that may cause an upset to homeostasis is stress. It is a fundamental part of living that can have both positive and negative effects on an individual’s health. Stress is not a medical diagnosis, but severe stress that continues for a long time may lead to a diagnosis of depre...
IN-VIVO STUDY OF ANTILITHIATIC ACTIVITY ON THE FRUITS EXTRACTS OF COCCINIA INDICA (WIGHT & ARN.) ETHYLENE GLYCOL INDUCED LITHIATIC IN RATS
Aim of the study: The aim of this study was to investigate the effect of ethanolic extract of fruits Coccinia indica Wight & Arn. (Cucurbitaceae) on urolithiasis in rats. Materials & methods: Thirty-six male rats were randomly divided into six groups (n = 6). Ethylene glycol (EG) 0.75% in drinking water were fed to all groups (Groups II-VI) except normal control (Group I) rats for 15-28...
Strobilanthes sessilis Nees is small perennial shrub, found on Kas plateau of Western Ghats in India. Its standardized Marathi name is Mal Karvy. This shrub belongs to the genus Strobilanthes which was first scientifically described by Nees in the 19th century. Scientific information on its Pharmacognosy, Phytochemistry is very scant. Hence the current study describes some Pharmacognostical, Physi...