IN-VITRO, EX-VIVO SKIN PERMEATION AND BIOLOGICAL EVALUATION OF 18-β-GLYCYRRHITIC ACID TRANSDERMAL PATCHES
Objective: a Transdermal patch is a promising approach that allows continuous input of drugs with short biological half-lives. 18 β-Glycyrrhizic acid (GA) is chemically pentacyclic triterpenoid which possesses powerful anti-inflammatory action. The present study was designed to formulate GA reservoir-type transdermal patches using piperine as bioenhancer. Method: Transdermal Patch of GA was prepa...
Essential hypertension (HTN) is the most prevalent type of HTN, affecting 90 to 95% of hypertensive patients. HTN accounts for a large proportion of all deaths and disability worldwide. It has been predicted that by the year 2020, there will be an increase of almost 75% in the global cardiovascular disease burden because of hypertension. Persistent HTN is one of the risk factors for strokes, heart...
The wound healing activity of leaves of Ficus racemosa Linn. alcoholic, chloroform and ethyl acetate extract ointments were evaluated on Wistar rats by excision wound model for 12 days and incision wound model for 10 days. In incision model the parameter carried out was tensile strength of wounded skin. In excision model percentage wound contractions were determined for all the groups. Reference s...
EVALUATION OF THE ANTIOXIDANT AND ANTI-PROLIFERATIVE CHEMICAL CONSTITUENTS OF HYPTIS PECTINATA (LINN.) AERIAL INFUSION
Objective: To evaluate the chemical composition, antioxidant and antiproliferative activities of Hyptis pectinata aerial part aqueous extract (HYP). Method: Chemical profiling using high-performance liquid chromatography with UV diode array detector (HPLC-UV-DAD), in-vitro antioxidant and anti-proliferative studies were done. Antioxidant and antiradical activities of HYP was investigated using 3-(...
Anethum graveolens an important medicinal plant and one of the most widely cultivated species of the family (Umbelliferae). It is highly valued from time immemorial because of its vast medicinal properties. The present work deals with the investigation of the laxative activity of various extracts of Anethum graveolens fruits. The laxative effect was checked in using Wister strain Albino rats. All ...
Purpose: The aim of the present study was to investigate the wound healing activity of the selected Indian medicinal plants Terminalia chebula, Terminalia bellarica, Ficus racemosa, Piper nigrum, Zingiber officinalis. Method: Excision and incision models for diabetes-induced rats at specified varying doses. Result: The plants showed a definite, positive effect on wound healing. Conclusion: The eff...
PHARMACOGNOSTIC, PHYTOCHEMICAL AND ANTI-INFLAMMATORY ACTIVITY OF MARTYNIYA ANNUA LEAVES LINN. (FAMILY: MARTYNIACEAE)
The present research was conducted to investigate the anti-inflammatory activity of methanolic extracts of plants of Martynia annua. (Family: Martyniaceae) The anti-inflammatory activity of the methanolic extracts of the Martynia annua at the dose of 50, 100, 200 mg/kg body weight was evaluated against the standard drug - pentazocine at a dose of 25 mg/kg body weight. Adult Swiss albino mice of ei...
PHYTOCHEMICAL ANALYSIS AND EFFECTS OF AQUEOUS EXTRACT OF WITHANIA SOMNIFERA ON ISOLATED SMOOTH MUSCLE, PERFUSED HEART, BLOOD PRESSURE AND DIURESIS IN RATS
The plant Withania somnifera has many acclaimed medicinal uses. This work aims to explore the efficacy of the aqueous extract (AE) of W. somnifera on the isolated trachea and aorta rings, perfused heart, blood pressure and diuresis in rats. Phytochemical analysis of the whole plant of W. somnifera was carried out using standard extraction procedures followed by column chromatography. An aqueous ex...
Andrographis paniculata Nees is a plant that has been effectively used in traditional Asian medicines for centuries. It’s perceived “blood purifying” property and also for medicinal properties. The present paper deals to study the phytochemical screening of Andrographis paniculata for various medicinally important compounds. In the present investigation, it was found that phenols, alkaloids,...
COSMETIC EVALUATION OF SOME IRANIAN COMMERCIAL NORMAL HAIR SHAMPOOS AND COMPARISION WITH NEW DEVELOPED FORMULATION
Four commercial normal hair shampoos produced by four famous Iranian companies were chosen for evaluating their characteristics based on scientifically measurable properties and were compared with our new developed formulation. Selection of the evaluation parameters of shampoo is a challenging test, because of the multitude of both subjective and instrumental test methodologies available for this ...