IN SILICO PREDICTION OF RIBOSWITCH AS A POTENTIAL DRUG TARGET AND DESIGN OF ITS OPTIMAL INHIBITORS AND PHARMACOPHORE FOR BACILLUS CEREUS
Bacillus cereus is a gram-positive, rod-shaped, motile, beta hemolytic bacteria. These bacteria cause foodborne illness, severe nausea, vomiting, diarrhea, and keratitis. Foodborne illness caused by Bacillus cereus occurs because of the bacterial endospores survival in improperly cooked food. The bacteria produce enterotoxins having high resistance against heat and acids, and they cause the diarrh...
THE MECHANISTIC APPROACH OF THE PROPYLENE GLYCOL AS A CO-SURFACTANT THROUGH “SIX MEMBER CYCLIC HYDROGEN BONDING SYSTEM” FOR THE STABLE AND FLEXIBLE MICROEMULSION DRUG CARRIER
The improvisation of any system has been a challenging task for the scientist in the field of drug delivery. In pursuit of the stable carrier system, here the microemulsion or other meta-state like liquid crystal phase with the specific mechanism, i.e., “six-member stable cyclic system” is highlighted and critically evaluated. The system with co-surfactant (propylene glycol) is examined and co...
COMPARATIVE PHARMACOGNOSY AND PHYTOCHEMICAL ANALYSIS OF MEDICINAL PLANTS WITH ANTIDIABETIC ACTIVITY (PTEROCARPUS MARSUPIUM ROXB., AZADIRACHTA INDICA A. JUSS., TRICHOSANTHES DIOICA ROXB., SYZYGIUM CUMINI LINN. AND MOMORDICA CHARANTIA LINN.)
Diabetes mellitus is becoming a threat to the world’s population as it is spreading like an epidemic. Pterocarpus marsupium Roxb., Azadirachta indica A. Juss., Trichosanthes dioica Roxb., S. cumini Linn. and M. charantia Linn. are well known for their properties in the management of diabetes. In recent times, there has been significant growth in the field of Ayurvedic medicines because of their ...
PRELIMINARY TISSUE CULTURE STUDY OF THE CALLUS PRODUCED FROM THE AERIAL PARTS OF ANTIGONON LEPTOPUS (HOOK & ARN)
Antigonon leptopus Hook & Arn (family Polygonaceae), also called: Chain of love, Queen’s Wreath and Mexican creeper is a fast-growing vine with stems reaching up to 20 feet long. It has heart-shaped, green leaves climbing by tendrils which wrap around many types of supports. It is native to Mexico and commonly found in tropical Asia, Africa, the Caribbean, and the Americas. It possesses anti...
ANABOLIC EFFECT ON BONE FORMATION OF NANO ENCAPSULATED VOLATILE OIL OF RUTA GRAVEOLENS LEAVES IN LARVAL ZEBRAFISH MODEL
Aim: The present research aims to screen anabolic activity on bone formation and bone density in normal and Teriparatide (Rh PTH biosynthetic human parathyroid hormone 1-34) induced inhibition of osteogenesis in zebrafish larval model to alleviate osteoporosis and other bone and joint disease or disorders of the Nano encapsulated essential oil isolated from the Ruta graveolens (NELVORG) Family: Ru...
Introduction: Obesity is associated with DM Type-II. The major basis for the association between these two is the ability of obesity to engender insulin resistance. Insulin resistance is a fundamental aspect of etiology of DM Type-II. Different factors increase insulin resistance, but FFA is the most common factor to increase insulin resistance. Aims and Objectives: Most of the obese person (80%) ...
Trianthema decandra Linn., belongs to family Aizoaceae, commonly known as “Punarnavi” in Sanskrit, “Gadabandi” in Hindi, and “Vellai sharuni” in Tamil. This plant is globally distributed tropical and subtropical regions. In India, it grows in dry-soil lands. It has been known since ancient times for curative properties and has been utilized for treatment of various ailments such as bur...
The purpose of the study was to determine the leaves of Andrographis serpyllifolia for anti-diabetic and antihyperlipidemic effects in streptozotocin-induced diabetic rats. The aqueous, alcoholic and hydroalcoholic extracts of Andrographis serpyllifolia were tested for toxicity up to 4000 mg kg-1 as per OECD-425 guidelines. Anti-diabetic activity was assessed by oral glucose tolerance test and str...
This study evaluated the scientific basis for the traditional use of Aegiceras corniculatum (Myrsinaceae) stem extract as an anthelmintic agent. The study design was an investigation of the traditional anthelmintic medicinal plant Aegiceras corniculatum using in-vitro anthelmintic properties of four extracts of the plant were evaluated using earthworms. The earthworm (Pheretima posthuma) resembles...
Stroke is the sudden blockage or rupture of cerebral arteries that can lead to cerebral damage or clinical neurologic deficit. Generally, stroke is as ischemic and hemorrhagic. Ischemia caused by factors such as thrombosis, embolism, and systemic hypoperfusion. Stroke is one of the most important factors of mortality and disability worldwide. After a stroke, an increase of free radicals has the mo...